产品货号：
JN2092
中文名称：
重组SARS-CoV-2 S1-RBD-SD1(His标签)
英文名称：
Recombinant SARS-CoV-2 S1 Protein RBD-SD1 (C-6His)
产品规格：
50μg|500μg|1mg
发货周期：
1～3天
产品价格：
询价
本制品由哺乳动物表达系统制备，目的基因编码表达SARS-CoV-2刺突蛋白S1亚单位受体结合域SD1片段(Gln14-Arg685)，C端带有一个6*His标签，用作免疫原或标准品。
技术指标：
Accession#：QHD43416.1
分子量：31.4kDa
实测分子量：35-43kDa（还原条件下）
纯度：＞95%（还原性SDS-PAGE）
纯化方式：亲和色谱法
贮存液：PBS，pH7.4，0.2μm过滤
保存条件：-20℃。
背景资料：
Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation,apoptosis,cancer development and progression,and the innate immune response.Known receptors bind S1 are ACE2,angiotensin-converting enzyme 2,DPP4,CEACAM etc..The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process.Most notable is severe acute respiratory syndrome (SARS).The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion.It is also a major immunogen and a target for entry inhibitors.It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor.The spike protein is a large type I transmembrane protein containing two subunits,S1 and S2.S1 mainly contains a receptor binding domain (RBD),which is responsible for recognizing the cell surface receptor.S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses,as well as protective immunity.
相关搜索：重组SARS-CoV-2 S1-RBD-SD1(His标签)，重组新型冠状病毒S蛋白受体结合域SD1片段(Arg319-Ser591)，重组新冠病毒S蛋白S1亚单位受体结合域SD1片段，重组S1-RBD-SD1，重组S-RBD-SD1
技术指标：
Accession#：QHD43416.1
分子量：31.4kDa
实测分子量：35-43kDa（还原条件下）
纯度：＞95%（还原性SDS-PAGE）
纯化方式：亲和色谱法
贮存液：PBS，pH7.4，0.2μm过滤
保存条件：-20℃。
| SDS-PAGE： | SEC-HPLC： |
 |  |
| 生物活性： | |
 |  |
| Immobilized SARS-CoV-2 S1-RBD-SD1-His(Cat#JN2092) at 5μg/ml (100μl/well) can bind Human ACE-2-Fc(Cat#JN2061).The ED50 of Recombinant Human ACE-2-Fc(Cat#JN2061) is 76ng/ml. | Immobilized SARS-CoV-2 S1-RBD-SD1-His(Cat#JN2092) at 5μg/ml (100μl/well) can bind Anti-SARS-CoV-2 S1 mAb(Cat#JN4025).The ED50 of Anti-SARS-CoV-2 S1 mAb (Cat#JN4025) is 2.2ng/ml. |
背景资料：
Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation,apoptosis,cancer development and progression,and the innate immune response.Known receptors bind S1 are ACE2,angiotensin-converting enzyme 2,DPP4,CEACAM etc..The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process.Most notable is severe acute respiratory syndrome (SARS).The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion.It is also a major immunogen and a target for entry inhibitors.It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor.The spike protein is a large type I transmembrane protein containing two subunits,S1 and S2.S1 mainly contains a receptor binding domain (RBD),which is responsible for recognizing the cell surface receptor.S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses,as well as protective immunity.
相关搜索：重组SARS-CoV-2 S1-RBD-SD1(His标签)，重组新型冠状病毒S蛋白受体结合域SD1片段(Arg319-Ser591)，重组新冠病毒S蛋白S1亚单位受体结合域SD1片段，重组S1-RBD-SD1，重组S-RBD-SD1