产品货号：
JN1945
中文名称：
重组人核仁蛋白3(NOL3)
英文名称：
Recombinant Human Nucleolar Protein 3
产品规格：
10μg|50μg|500μg|1mg
发货周期：
1～3天
产品价格：
询价
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Met1-Ser208表达纯化得来。
NOL3质量控制：＞95%(还原性SDS-PAGE)
NOL3制剂：液体
NOL3保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。
关于NOL3：
Nucleolar protein 3 is encoded by NOL3 gene. Multiple transcript variants encoding different isoforms have been found for this gene. So far, Nucleolar protein 3 has show to have two Isoforms. Isoform 1 may be involved in RNA splicing. Isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death.It inhibits extrinsic apoptotic pathways through two different ways. Firstly, it by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly. Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation. It has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53.
相关搜索：重组人核仁蛋白3(NOL3)，Recombinant Human Nucleolar Protein 3
NOL3质量控制：＞95%(还原性SDS-PAGE)
NOL3制剂：液体
NOL3保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。
关于NOL3：
Nucleolar protein 3 is encoded by NOL3 gene. Multiple transcript variants encoding different isoforms have been found for this gene. So far, Nucleolar protein 3 has show to have two Isoforms. Isoform 1 may be involved in RNA splicing. Isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death.It inhibits extrinsic apoptotic pathways through two different ways. Firstly, it by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly. Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation. It has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53.
相关搜索：重组人核仁蛋白3(NOL3)，Recombinant Human Nucleolar Protein 3