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产品目录

重组人Lacritin蛋白(LACRT)图片
产品货号:
JN1941
中文名称:
重组人Lacritin蛋白(LACRT)
英文名称:
Recombinant Human Lacritin
产品规格:
10μg|50μg|500μg|1mg
发货周期:
1~3天
产品价格:
询价
本品由我们的大肠杆菌表达系统制备而成,目的基因编码的Ala19-Ala138在N端含有His标签。

Lacritin/LACRT质量控制:>95%(还原性SDS-PAGE)

Lacritin/LACRT制剂:冻干品

Lacritin/LACRT保存
冻干蛋白置于-20℃以下可长期保存,室温条件下可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天,可分装后置于-20℃保存三个月。

Lacritin/LACRT复溶
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后,请根据用量分装冻存,避免反复冻融。

关于Lacritin/LACRT
Extracellular glycoprotein lacritin (Lacritin) is a secreted protein which consists of 119 amino acids after cleavage of the N-terminal signal peptide and displays several predicted alpha helices, mostly in the C-terminal half. Lacritin is highly expressed in the lacrimal gland, localizes primarily to secretory granules and secretory fluid. Lacritin modulates lacrimal acinar cell secretion, promotes ductal cell proliferation, and stimulates signaling through tyrosine phosphorylation and release of calcium. Lacritin is thus a multifunctional prosecretory mitogen with cell survival activity. Natural or bacterial cleavage of lacritin releases a C-terminal fragment that is bactericidal. Lacritin cell targeting is dependent on the cell surface heparan sulfate proteoglycan syndecan-1 (SDC1). Binding utilizes an enzyme-regulated off-on switch in which active epithelial heparanase (HPSE) cleaves off heparan sulfate to expose a binding site in the N-terminal region of syndecan-1s core protein.
相关搜索:重组人Lacritin蛋白(LACRT)Recombinant Human Lacritin
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