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产品目录

重组人DUSP3图片
产品货号:
JN1781
中文名称:
重组人DUSP3
英文名称:
Recombinant Human Vaccinia Virus VH1-related Phosphatase
产品规格:
10μg|50μg|500μg|1mg
发货周期:
1~3天
产品价格:
询价
本品由我们的大肠杆菌表达系统制备而成,目的基因编码的Ser2-Pro185在N端含有His标签。

DUSP3质量控制:>95%(还原性SDS-PAGE)

DUSP3制剂:液体

DUSP3保存:收到货后请置于-20℃,可保存6个月,避免反复冻融。

关于DUSP3
Human DUSP3 belongs to the dual specificity protein phosphatase subfamily. DUSPs are a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the one substrate. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. DUSPs are major modulators of critical signalling pathways that are dysregulated in various diseases. They negatively regulate members of the mitogen-activated protein kinase superfamily, which are associated with cellular proliferation and differentiation. DUSP3 is expressed in human tissues including breast and ovarian.DUSP3 shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Human DUSP3 specifically dephosphorylates and inactivates ERK1 and ERK2.
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