产品货号：
JN1036
中文名称：
重组人泛素结合酶E2-M(UBCE2M)
英文名称：
Recombinant Human Ubiquitin-conjugating Enzyme E2M
产品规格：
10μg|50μg|500μg|1mg
发货周期：
1～3天
产品价格：
询价
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Met1-Lys183表达纯化得来。
UBE2M质量控制：＞95%(还原性SDS-PAGE)
UBE2M制剂：液体
UBE2M保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。
关于UBE2M：
UBE2M is a member of the E2 ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. UBE2M accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. It involved in cell proliferation and is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation.
相关搜索：重组人泛素结合酶E2-M(UBCE2M)
UBE2M质量控制：＞95%(还原性SDS-PAGE)
UBE2M制剂：液体
UBE2M保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。
关于UBE2M：
UBE2M is a member of the E2 ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. UBE2M accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. It involved in cell proliferation and is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation.
相关搜索：重组人泛素结合酶E2-M(UBCE2M)