产品货号：
JN0416
中文名称：
重组小鼠白介素IL-4
英文名称：
Recombinant Mouse Interleukin-4
产品规格：
10μg|50μg|500μg|1mg
发货周期：
1～3天
产品价格：
询价
重组小鼠IL-4由大肠杆菌表达系统产生，并表达编码His23-Ser140的靶基因。
Interleukin-4;B-cell IgG differentiation factor;B-cell growth factor 1;B-cell stimulatory factor 1;IGG1 induction factor;Lymphocyte stimulatory factor 1;IL-4;BSF-1
保存：-20℃，有效期1年。
Mouse Interleukin-4(IL-4) is a monomeric,Th2 cytokine that shows pleiotropic effects during immune responses.It is a glycosylated polypeptide that contains three intrachain disulfide bridges and adopts a bundled four α-helix structure.IL-4 exerts its effects through two receptor complexes,Participates in at least several B-cell activation processes as well as of other cell types.IL-4 is primarily expressed by Th2-biased CD4+T cells,mast cells,basophils,and eosinophils.It promotes cell proliferation,survival,and immunoglobulin class switch to IgG1 and IgE in mouse B cells,acquisition of the Th2 phenotype by na?ve CD4+T cells,priming and chemotaxis of mast cells,eosinophils,and basophils,and the proliferation and activation of epithelial cells.IL-4 plays a dominant role in the development of allergic inflammation and asthma.It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
在M-NFS-60小鼠淋巴母细胞的细胞增殖实验中测定，该效应的ED50为0.01ng/mL。
相关搜索：重组小鼠白介素IL-4，白细胞介素4，Recombinant Mouse Interleukin-4
Interleukin-4;B-cell IgG differentiation factor;B-cell growth factor 1;B-cell stimulatory factor 1;IGG1 induction factor;Lymphocyte stimulatory factor 1;IL-4;BSF-1
| 分子量 | 13.4 KDa |
| 表观分子量 | 14 KDa（还原条件下） |
| 供货形式 | 冻干制剂，0.2μm过滤 |
| 保存液 | 20mM PB,300mM NaCl,5% Trehalose,pH6.5。 |
| 内毒素 | ＜1 EU/μg （LAL） |
| 组分 | 10μg | 50μg | 500μg | 1mg |
| 重组小鼠白介素IL-4 | 10μg | 50μg | 500μg | 1mg |
| 说明书 | 1份 | |||
保存：-20℃，有效期1年。
- 重组小鼠IL-4冻干蛋白在-20℃可稳定保存一年。
- 复溶蛋白溶液可在4～7℃保存2～7天。
- 复溶后建议分装冻存在-20℃，可保存3个月，应避免反复冻融。
- 试剂开盖前请先离心，不要通过vortex或移液管混合。
- 复溶浓度应大于100μg/mL。
- 用ddH2O溶解冻干小鼠IL-4蛋白
- 复溶后根据使用量分装保存，避免反复冻融。
Mouse Interleukin-4(IL-4) is a monomeric,Th2 cytokine that shows pleiotropic effects during immune responses.It is a glycosylated polypeptide that contains three intrachain disulfide bridges and adopts a bundled four α-helix structure.IL-4 exerts its effects through two receptor complexes,Participates in at least several B-cell activation processes as well as of other cell types.IL-4 is primarily expressed by Th2-biased CD4+T cells,mast cells,basophils,and eosinophils.It promotes cell proliferation,survival,and immunoglobulin class switch to IgG1 and IgE in mouse B cells,acquisition of the Th2 phenotype by na?ve CD4+T cells,priming and chemotaxis of mast cells,eosinophils,and basophils,and the proliferation and activation of epithelial cells.IL-4 plays a dominant role in the development of allergic inflammation and asthma.It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
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| 图1．还原SDS-PAGE检测，纯度＞95% | 图2．SEC-HPLC检测，纯度＞95% |
在M-NFS-60小鼠淋巴母细胞的细胞增殖实验中测定，该效应的ED50为0.01ng/mL。
相关搜索：重组小鼠白介素IL-4，白细胞介素4，Recombinant Mouse Interleukin-4