产品货号：
GS4912
中文名称：
重组小鼠IL-36γ,152a.a.
英文名称：
Recombinant Murine Interleukin-36 gamma, 152a.a. (rMuIL-36γ, 152a.a.)
产品规格：
2μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 17.3kDa,a single non-glycosylated polypeptide chain containing 152 amino acids.
储存条件：冷冻（-20℃）
概述
Interleukin-36(IL-36)is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases.IL-36α,IL-36β,and IL-36γ(formerly IL-1F6,IL-1F8,and IL-1F9)are IL-1 family members that signal through the IL- 1 receptor family members IL-1Rrp2(IL-1RL2)and IL-1RAcP.IL-36γ is secreted when transfected into 293-T cells and it could constitute part of an independent signaling system analogous to interleukin-1 alpha(IL-1A),beta(IL-1B)receptor agonist and interleukin-1 receptor type I(IL-1R1).Furthermore,IL-36γ also can function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2.Recombinant murine IL-36γ is synthesized as a 17.3kDa,152 amino acid(a.a.)protein.Murine to human,IL-36γ shares 53%a.a.identity.Within the family,IL-36γ shares about 25%~55%a.a.sequence identity with IL-1RA,IL-1β,IL-36RA,IL-36α,IL-37,IL-36β and IL-1F10.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组小鼠IL-36γ,152a.a.，IL-36γ, 152a.a., Murine
储存条件：冷冻（-20℃）
概述
Interleukin-36(IL-36)is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases.IL-36α,IL-36β,and IL-36γ(formerly IL-1F6,IL-1F8,and IL-1F9)are IL-1 family members that signal through the IL- 1 receptor family members IL-1Rrp2(IL-1RL2)and IL-1RAcP.IL-36γ is secreted when transfected into 293-T cells and it could constitute part of an independent signaling system analogous to interleukin-1 alpha(IL-1A),beta(IL-1B)receptor agonist and interleukin-1 receptor type I(IL-1R1).Furthermore,IL-36γ also can function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2.Recombinant murine IL-36γ is synthesized as a 17.3kDa,152 amino acid(a.a.)protein.Murine to human,IL-36γ shares 53%a.a.identity.Within the family,IL-36γ shares about 25%~55%a.a.sequence identity with IL-1RA,IL-1β,IL-36RA,IL-36α,IL-37,IL-36β and IL-1F10.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞98%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by inducing IL-6 secretion in murine NIH/3T3 cells is less than 10ng/ml,corresponding to a specific activity of>1.0×105 IU/mg. |
| 成分 | Lyophilized froma 0.2μmfiltered concentrated solution in 20mMTris-HCl,pH 8.5,150mM NaCl with Tween-20. |
| 内毒素 | Less than 0.1 EU/μg of rMuIL-36γ,152a.a.as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20?C.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | GRETPDFGEV FDLDQQVWIF RNQALVTVPR SHRVTPVSVT ILPCKYPESL EQDKGIAIYL GIQNPDKCLF CKEVNGHPTL LLKEEKILDL YHHPEPMKPF LFYHTRTGGT STFESVAFPG HYIASSKTGN PIFLTSKKGE YYNINFNLDI KS |
相关搜索：重组小鼠IL-36γ,152a.a.，IL-36γ, 152a.a., Murine