产品货号：
GS4911
中文名称：
重组马IL-2 Cys141Ser
英文名称：
Recombinant Equine Interleukin-2 Cys141Ser (rEqIL-2 Cys141Ser)
产品规格：
2μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 14.9kDa,a single non-glycosylated polypeptide chain containing 129 amino acids.
储存条件：冷冻（-20℃）
概述
IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation.It is expressed by CD4+ and CD8+ T cells,γδ T cells,B cells,dendritic cells,and eosinophils.IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response.The receptor for IL-2 consists of three subunits(55 kDa IL2Rα,75 kDa IL2Rβ,64 kDa common gamma chain γc/IL2Rγ)that are present on the cell surface in varying preformed complexes.Recombinant equine IL-2 is a 14.9 kDa protein containing 129 amino acid residues.At the amino acid sequence level,equine IL-2 shares 72%,70%,56%and 54%sequence similarities with human,porcine,rat and murine IL-2,respectively.It has been reported that equine IL-2 augmented proliferation in equine peripheral blood mononuclear cells,but has no effect on murine CTLL2 cells.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组马IL-2 Cys141Ser，IL-2 Cys141Ser, Equine
储存条件：冷冻（-20℃）
概述
IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation.It is expressed by CD4+ and CD8+ T cells,γδ T cells,B cells,dendritic cells,and eosinophils.IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response.The receptor for IL-2 consists of three subunits(55 kDa IL2Rα,75 kDa IL2Rβ,64 kDa common gamma chain γc/IL2Rγ)that are present on the cell surface in varying preformed complexes.Recombinant equine IL-2 is a 14.9 kDa protein containing 129 amino acid residues.At the amino acid sequence level,equine IL-2 shares 72%,70%,56%and 54%sequence similarities with human,porcine,rat and murine IL-2,respectively.It has been reported that equine IL-2 augmented proliferation in equine peripheral blood mononuclear cells,but has no effect on murine CTLL2 cells.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞97%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using murine CTLL-2 cells is less than 1.0μg/ml,corresponding to a specific activity of>1000 IU/mg. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 6.5. |
| 内毒素 | Less than 0.1 EU/μg of rEqIL-2 Cys141Ser as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | APTSSSKRET QQQLKQLQMD LKLLLEGVNN NKNPKLSKML TFKINMPKKA TELKHLQCLE EELKPLEEML KNFLSKDIKE LMSNINVTVL GLKGSETRFT CEYDDETGTI VEFLNKWITF SQSIFSTMT |
相关搜索：重组马IL-2 Cys141Ser，IL-2 Cys141Ser, Equine