产品货号：
GS4909
中文名称：
重组马IL-1RA
英文名称：
Recombinant Equine Interleukin-1 Receptor Antagonist ( rEqIL-1RA)
产品规格：
5μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 17.4kDa,a single non-glycosylated polypeptide chain containing 152 amino acids.
储存条件：冷冻（-20℃）
概述
IL-1RA was initially called the IL-1 inhibitor which is encoded by the IL1RN gene and it is a member of the interleukin 1 cytokine family.It is secreted by various types of cells including immune cells,epithelial cells,and adipocytes.IL-1RA has functions of inhibiting the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling.IL-1RA is also used in the treatment of rheumatoid arthritis,an autoimmune disease in which IL-1 plays a key role.The equus caballus IL-1RA is a singlenon-glycosylated polypeptide chain containing 152 aminoacids and It has been shown to block the inflammatory responses induced by IL-1bothinvitroandinvivo.Theproteinshows26%amino acid homology to IL-1β and 19%homology to IL-1α.It also shares 78%~80%a.a.sequence identity with murine,rat,porcine IL-1RA.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组马IL-1RA，IL-1RA, Equine
储存条件：冷冻（-20℃）
概述
IL-1RA was initially called the IL-1 inhibitor which is encoded by the IL1RN gene and it is a member of the interleukin 1 cytokine family.It is secreted by various types of cells including immune cells,epithelial cells,and adipocytes.IL-1RA has functions of inhibiting the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling.IL-1RA is also used in the treatment of rheumatoid arthritis,an autoimmune disease in which IL-1 plays a key role.The equus caballus IL-1RA is a singlenon-glycosylated polypeptide chain containing 152 aminoacids and It has been shown to block the inflammatory responses induced by IL-1bothinvitroandinvivo.Theproteinshows26%amino acid homology to IL-1β and 19%homology to IL-1α.It also shares 78%~80%a.a.sequence identity with murine,rat,porcine IL-1RA.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze- dried)powder. |
| 纯度 | ＞95%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by inhibiting IL-1α- dependent proliferation of murine D10S cells is less than 3.0μg/ml,corresponding to a specific activity of>333 IU/mg in the presence of 50pg/ml rHuIL-1α. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4. |
| 内毒素 | Less than 1 EU/μg of rEqIL-1RA as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | HPLGKRPCKM QAFRIWDVNQ KTFYMRNNQL VAGYLQESNT KLQEKIDVVP IEPDALFLGL HGRKLCLACV KSGDEIRFQL EAVNITDLSK NKEENKRFTF IRSNSGPTTS FESAACPGWF LCTAQEADRP VSLTNKPKES FMVTKFYLQE DQ |
相关搜索：重组马IL-1RA，IL-1RA, Equine