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产品目录

重组人Bcl-2图片
产品货号:
GS4905
中文名称:
重组人Bcl-2
英文名称:
Recombinant Human B-cell Lymphoma 2
产品规格:
5μg
发货周期:
1~3天
产品价格:
询价
分子量:Approximately 23.2kDa,a single non-glycosylated polypeptide chain containing 210 amino acids.
储存条件:冷冻(-20℃)

概述

B-cell lymphoma 2(Bcl-2)is the founding member of the Bcl-2 family and it is encoded by the BCL2 gene in human.Bcl-2
forms homodimer and heterodimers with other Bcl-2 family proteins,like BAX,BAK,BAD and Bcl-xL.Alternative splicing of
Bcl-2 results in two isoforms with similar folds despite differences in anti-apoptotic activity.Bcl-2 suppresses apoptosis by
controlling the mitochondrial membrane permeability.It inhibits caspase activity either by preventing the release of cytochrome c
from the mitochondria and/or by binding to the apoptosis-activating factor(APAF-1).Antibodies to Bcl-2 can be used with
immunohistochemistry to identify cells containing the antigen.In some cases,the presence or absence of Bcl-2 staining in
biopsies may be significant for the patients prognosis or likelihood of cancer relapse.Mature human Bcl-2 shares 88%- 90%
amino acid sequence identity with murine,rat,bovine,canine Bcl-2.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further
evaluation purposes.NOT FOR HUMAN USE.

技术规格

外观Sterile liquid.
Purity:>95%by SDS-PAGE and HPLC analyses.
Source:Escherichia coli.
Biological Activity:Test in Process.
Formulation:0.2μmfiltered concentrated solution in 25mMTris-HCl,pH 8.0,100mM NaCl,1 mM DTT,30%
Glycerol,with Tween-80.
内毒素Less than 0.1 EU/μg of rHuBcl-2 as determined by LAL method.
氨基酸序列AHAGRTGYDN REIVMKYIHY KLSQRGYEWD AGDVGAAPPG AAPAPGIFSS
QPGHTPHPAA SRDPVARTSP LQTPAAPGAA AGPALSPVPP VVHLTLRQAG
DDFSRRYRRD FAEMSSQLHL TPFTARGRFA TVVEELFRDG VNWGRIVAFF
EFGGVMCVES VNREMSPLVD NIALWMTEYL NRHLHTWIQD NGGWDAFVEL
YGPSMRPLFD

相关搜索:重组人Bcl-2Bcl-2, HumanRecombinant Human B-cell Lymphoma 2
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