产品货号：
GS4896
中文名称：
重组人MIC-A
英文名称：
Recombinant Human MHC Class I Polypeptide-Related Sequence A
产品规格：
10μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 32.8kDa,a single non-glycosylated polypeptide chain containing 285 amino acids.
储存条件：冷冻（-20℃）
概述
MIC-A(MHC class I chain-related gene A)is a single-pass type I member protein.It is expressed on the cell surface in gastric epithelium,endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes.Additionally,MIC-A can be induced by bacterial and viral infections.It shares 85%amino acid identity with MIC-B and they are distantly related to the MHC class I proteins.Because they possess three extracellular Ig-like domains,but unlike classical MHC class I molecules.They do not form a heterodimer with beta2 microglobulin,but bind as a monomer to a KLRK1/NKG2D that is an activating receptor expressed on NK cells,NKT cells,γδ T cells,and CD8+ αβ T cells.Recognition of MICA by NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells.MIC-A recognition plays an important role in tumor surveillance,viral infections,and autoimmune diseases.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组人MIC-A，MIC-A, Human
储存条件：冷冻（-20℃）
概述
MIC-A(MHC class I chain-related gene A)is a single-pass type I member protein.It is expressed on the cell surface in gastric epithelium,endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes.Additionally,MIC-A can be induced by bacterial and viral infections.It shares 85%amino acid identity with MIC-B and they are distantly related to the MHC class I proteins.Because they possess three extracellular Ig-like domains,but unlike classical MHC class I molecules.They do not form a heterodimer with beta2 microglobulin,but bind as a monomer to a KLRK1/NKG2D that is an activating receptor expressed on NK cells,NKT cells,γδ T cells,and CD8+ αβ T cells.Recognition of MICA by NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells.MIC-A recognition plays an important role in tumor surveillance,viral infections,and autoimmune diseases.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞95%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The specific activity is determined by binding MICA antibody in ELISA. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4. |
| 内毒素 | Less than 1 EU/μg of rHuMIC-A,His as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | EPHSLRYNLT VLSWDGSVQS GFLAEVHLDG QPFLRYDRQK CRAKPQGQWA EDVLGNKTWD RETRDLTGNG KDLRMTLAHI KDQKEGLHSL QEIRVCEIHE DNSTRSSQHF YYDGELFLSQ NLETEEWTVP QSSRAQTLAM NVRNFLKEDA MKTKTHYHAM HADCLQELRR YLESGVVLRR TVPPMVNVTR SEASEGNITV TCRASSFYPR NIILTWRQDG VSLSHDTQQW G |
相关搜索：重组人MIC-A，MIC-A, Human