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产品目录

重组人GM-CSF图片
产品货号:
GS4828
中文名称:
重组人GM-CSF
英文名称:
Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor
产品规格:
5μg
发货周期:
1~3天
产品价格:
询价
分子量:Approximately 14.5kDa,a single non-glycosylated polypeptide chain containing 127 amino acids.
储存条件:冷冻(-20℃)

概述

Granulocyte-Macrophage Colony Stimulating Factor(GM-CSF)is secreted by a number of different cell types(including activated T cells,B cells,macrophages,mast cells,endothelial cells and fibroblasts)in response to cytokine or immune and inflammatory stimulation.It was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors and has functions of stimulates the growth and differentiation of hematopoietic precursor cells from various lineages.GM-CSF has also been reported to have a functional role on non-hematopoietic cells and can induce human endothelial cells to migrate and proliferate.Additionally,it can stimulate the proliferation of a number of tumor cell lines,including osteogenic sarcoma,carcinoma and adenocarcinoma cell lines.Human GM-CSF shares 54%sequences identity with mouse GM-CSF,but has no biological effects across species.GM-CSF is used as a medication to stimulate the production of white blood cells following chemotherapy and has also recently been evaluated in clinical trials for its potential as a vaccine adjuvant in HIV-infected patients.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格

外观Sterile Filtered White lyophilized(freeze-dried)powder.
纯度>98%by SDS-PAGE and HPLC analyses.
来源Escherichia coli.
生物活性Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 0.1ng/ml,corresponding to a specific activity of>1.0×107 IU/mg.
成分Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4.
内毒素Less than 1.0 EU/μg of rHuGM-CSF as determined by LAL method.
复溶We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20?C.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列APARSPSPST QPWEHVNAIQ EARRLLNLSR DTAAEMNETV EVISEMFDLQ EPTCLQTRLE LYKQGLRGSL TKLKGPLTMM ASHYKQHCPP TPETSCATQI ITFESFKENL KDFLLVIPFD CWEPVQE

相关搜索:重组人GM-CSFGM-CSF, Human
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