产品货号：
GS4823
中文名称：
重组人IL-10
英文名称：
Recombinant Human Interleukin-10
产品规格：
2μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 18.6kDa,a single non-glycosylated polypeptide chain containing 160 amino acids.
储存条件：冷冻（-20℃）
概述
Interleukin-10(IL-10),also known as cytokine synthesis inhibitory factor(CSIF),is the charter member of the IL-10 family of α-helical cytokines that also includes IL-19,IL-20,IL-22,IL-24,and IL-26/AK155.IL-10 is secreted by many activated hematopoietic cell types as well as hepatic stellate cells,keratinocytes,and placental cytotrophoblasts.Whereas human IL-10 is active on mouse cells,mouse IL-10 does not act on human cells.IL-10 is a 178 amino acid molecule that contains two intrachain disulfide bridges and is expressed as a 36 k Da noncovalently associated homodimer.The IL-10 dimer binds to two IL-10 Rα/IL-10R1 chains,resulting in recruitment of two IL-10 Rβ/IL-10R2 chains and activation of a signaling cascade involving JAK1,TYK2,and STAT3.IL-10Rβ does not bind IL-10 by itself but is required for signal transduction.IL-10 is a critical molecule in the control of viral infections and allergic and autoimmune inflammation.It promotes phagocytic uptake and Th2 responses but suppresses antigen presentation and Th1 proinflammatory responses.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组人IL-10，IL-10, Human，Recombinant Human Interleukin-10
储存条件：冷冻（-20℃）
概述
Interleukin-10(IL-10),also known as cytokine synthesis inhibitory factor(CSIF),is the charter member of the IL-10 family of α-helical cytokines that also includes IL-19,IL-20,IL-22,IL-24,and IL-26/AK155.IL-10 is secreted by many activated hematopoietic cell types as well as hepatic stellate cells,keratinocytes,and placental cytotrophoblasts.Whereas human IL-10 is active on mouse cells,mouse IL-10 does not act on human cells.IL-10 is a 178 amino acid molecule that contains two intrachain disulfide bridges and is expressed as a 36 k Da noncovalently associated homodimer.The IL-10 dimer binds to two IL-10 Rα/IL-10R1 chains,resulting in recruitment of two IL-10 Rβ/IL-10R2 chains and activation of a signaling cascade involving JAK1,TYK2,and STAT3.IL-10Rβ does not bind IL-10 by itself but is required for signal transduction.IL-10 is a critical molecule in the control of viral infections and allergic and autoimmune inflammation.It promotes phagocytic uptake and Th2 responses but suppresses antigen presentation and Th1 proinflammatory responses.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞95%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using murine MC/9-2 cells is less than 1ng/ml,corresponding to a specific activity of>1.0×106 IU/mg. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4. |
| 内毒素 | Less than 1 EU/μg of rHuIL-10 as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | SPGQGTQSEN SCTHFPGNLP NMLRDLRDAF SRVKTFFQMK DQLDNLLLKE SLLEDFKGYL GCQALSEMIQ FYLEEVMPQA ENQDPDIKAH VNSLGENLKT LRLRLRRCHR FLPCENKSKA VEQVKNAFNK LQEKGIYKAM SEFDIFINYI EAYMTMKIRN |
相关搜索：重组人IL-10，IL-10, Human，Recombinant Human Interleukin-10