产品货号：
GS4822
中文名称：
重组人IL-6
英文名称：
Recombinant Human Interleukin-6
产品规格：
5μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 20.7kDa,a single non-glycosylated polypeptide chain containing 183 amino acids.
储存条件：冷冻（-20℃）
概述
Interleukin-6(IL-6)is an interleukin that in humans is encoded by the IL-6 gene and acts as both a pro-inflammatory and anti-inflammatory cytokine.It is secreted by T cells and macrophages to stimulate immune response.Furthermore,It plays an essential role in the final differentiation of B-cells into Ig-secreting cells involved in lymphocyte and monocyte differentiation.It also induces myeloma and plasmacytoma growth and induces nerve cells differentiation acts on B-cells,T-cells,hepatocytes,hematopoietic progenitor cells and cells of the CNS.The human IL-6 is a single non-glycosylated polypeptide chain containing 183 amino acids and it signals through a cell-surface type I cytokine receptor complex consisting of the ligand-binding IL-6Rα chain(CD126),and the signal- transducing component gp130(also called CD130).The human IL-6 shares about 40%a.a.sequence identity with mouse and rat IL-6 and it is equally active on mouse and rat cells.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组人IL-6，IL-6, Human，Recombinant Human Interleukin-6
储存条件：冷冻（-20℃）
概述
Interleukin-6(IL-6)is an interleukin that in humans is encoded by the IL-6 gene and acts as both a pro-inflammatory and anti-inflammatory cytokine.It is secreted by T cells and macrophages to stimulate immune response.Furthermore,It plays an essential role in the final differentiation of B-cells into Ig-secreting cells involved in lymphocyte and monocyte differentiation.It also induces myeloma and plasmacytoma growth and induces nerve cells differentiation acts on B-cells,T-cells,hepatocytes,hematopoietic progenitor cells and cells of the CNS.The human IL-6 is a single non-glycosylated polypeptide chain containing 183 amino acids and it signals through a cell-surface type I cytokine receptor complex consisting of the ligand-binding IL-6Rα chain(CD126),and the signal- transducing component gp130(also called CD130).The human IL-6 shares about 40%a.a.sequence identity with mouse and rat IL-6 and it is equally active on mouse and rat cells.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞96%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using IL-6-dependent murine 7TD1 cells is less than 0.1ng/ml,corresponding to a specific activity of>1.0×107 IU/mg. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4. |
| 内毒素 | Less than 1.0 EU/μg of rHuIL-6 as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | VPPGEDSKDV AAPHRQPLTS SERIDKQIRY ILDGISALRK ETCNKSNMCE SSKEALAENN LNLPKMAEKD GCFQSGFNEE TCLVKIITGL LEFEVYLEYL QNRFESSEEQ ARAVQMSTKV LIQFLQKKAK NLDAITTPDP TTNASLLTKL QAQNQWLQDM TTHLILRSFK EFLQSSLRAL RQM |
相关搜索：重组人IL-6，IL-6, Human，Recombinant Human Interleukin-6