产品货号：
GS4759
中文名称：
重组大鼠MIF
英文名称：
Recombinant Rat Migration Inhibitor Factor
产品规格：
10μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 12.5kDa,a single non-glycosylated polypeptide chain containing 115 amino acids.
储存条件：冷冻（-20℃）
概述
Macrophage migration inhibitory factor(MIF or MMIF),also named as glycosylation-inhibiting factor(GIF),L-dopachrome isomerase,or phenylpyruvate tautomerase,is a protein encoded by the MIF gene.It is released from white blood cells by bacterial antigen stimulation to trigger an acute immune response,or by glucocorticoids to counter-act the inhibitory effects of glucocorticoids on immune system.MIF is a homotrimer of which each subunit contains 115 amino acids.As mentioned above,MIF is involved in the innate immune response to bacterial pathogens and counter-acts the anti-inflammatory activity of glucocorticoids.Furthermore,it also plays a role as mediator in regulating the function of macrophages in host defense and has phenylpyruvate tautomerase and dopachrome tautomerase activity in vitro.Rat MIF is 99%,90%,89%,and 89%a.a.identical to human,murine,porcine and bovine,respectively.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组大鼠MIF，MIF, Rat，Recombinant Rat Migration Inhibitor Factor
储存条件：冷冻（-20℃）
概述
Macrophage migration inhibitory factor(MIF or MMIF),also named as glycosylation-inhibiting factor(GIF),L-dopachrome isomerase,or phenylpyruvate tautomerase,is a protein encoded by the MIF gene.It is released from white blood cells by bacterial antigen stimulation to trigger an acute immune response,or by glucocorticoids to counter-act the inhibitory effects of glucocorticoids on immune system.MIF is a homotrimer of which each subunit contains 115 amino acids.As mentioned above,MIF is involved in the innate immune response to bacterial pathogens and counter-acts the anti-inflammatory activity of glucocorticoids.Furthermore,it also plays a role as mediator in regulating the function of macrophages in host defense and has phenylpyruvate tautomerase and dopachrome tautomerase activity in vitro.Rat MIF is 99%,90%,89%,and 89%a.a.identical to human,murine,porcine and bovine,respectively.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞97%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Test in process. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in 20mMTris,pH 8.0,150 mM NaCl,3%trehalose. |
| 内毒素 | Less than 1 EU/μg of rRtMIF as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | MPMFIVNTNV PRASVPEGFL SELTQQLAQA TGKPAQYIAV HVVPDQLMTF SGTSDPCALC SLHSIGKIGG AQNRNYSKLL CGLLSDRLHI SPDRVYINYY DMNAANVGWN GSTFA |
相关搜索：重组大鼠MIF，MIF, Rat，Recombinant Rat Migration Inhibitor Factor