产品货号：
GS4754
中文名称：
重组小鼠MIF
英文名称：
Recombinant Murine Migration Inhibitor Factor
产品规格：
10μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 12.5kDa,a single non-glycosylated polypeptide chain containing 115 amino acids.
储存条件：冷冻（-20℃）
概述
Macrophage migration inhibitory factor(MIF or MMIF),also named as glycosylation-inhibiting factor(GIF),L-dopachrome isomerase,or phenylpyruvate tautomerase,is a protein encoded by the MIF gene.It is released from white blood cells by bacterial antigen stimulation to trigger an acute immune response,or by glucocorticoids to counter-act the inhibitory effects of glucocorticoids on immune system.MIF is a homotrimer of which each subunit contains 115 amino acids.As mentioned above,MIF is involved in the innate immune response to bacterial pathogens and counter-acts the anti-inflammatory activity of glucocorticoids.Furthermore,it also plays a role as mediator in regulating the function of macrophages in host defense and has phenylpyruvate tautomerase and dopachrome tautomerase activity in vitro.Mouse MIF is active on human cells,while human MIF is active on mouse cells.Mouse MIF is 99%,84%,90%,and 90%a.a.identical to rat,porcine,bovine and human MIF,respectively.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组小鼠MIF，MIF, Murine，Recombinant Murine Migration Inhibitor Factor
储存条件：冷冻（-20℃）
概述
Macrophage migration inhibitory factor(MIF or MMIF),also named as glycosylation-inhibiting factor(GIF),L-dopachrome isomerase,or phenylpyruvate tautomerase,is a protein encoded by the MIF gene.It is released from white blood cells by bacterial antigen stimulation to trigger an acute immune response,or by glucocorticoids to counter-act the inhibitory effects of glucocorticoids on immune system.MIF is a homotrimer of which each subunit contains 115 amino acids.As mentioned above,MIF is involved in the innate immune response to bacterial pathogens and counter-acts the anti-inflammatory activity of glucocorticoids.Furthermore,it also plays a role as mediator in regulating the function of macrophages in host defense and has phenylpyruvate tautomerase and dopachrome tautomerase activity in vitro.Mouse MIF is active on human cells,while human MIF is active on mouse cells.Mouse MIF is 99%,84%,90%,and 90%a.a.identical to rat,porcine,bovine and human MIF,respectively.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞96%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Bioassay data are not available. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4,1mMDTT. |
| 内毒素 | Less than 1 EU/μg of rMuMIF as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | MPMFIVNTNV PRASVPEGFL SELTQQLAQA TGKPAQYIAV HVVPDQLMTF SGTNDPCALC SLHSIGKIGG AQNRNYSKLL CGLLSDRLHI SPDRVYINYY DMNAANVGWN GSTFA |
相关搜索：重组小鼠MIF，MIF, Murine，Recombinant Murine Migration Inhibitor Factor