产品货号：
GS4660
中文名称：
重组人IL-36γ(169a.a.)
英文名称：
Recombinant Human Interleukin-36 gamma, 169a.a.
产品规格：
2μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 18.7kDa,a single non-glycosylated polypeptide chain containing 169 amino acids.
储存条件：冷冻（-20℃）
概述
Interleukin-36(IL-36)is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases.IL-36α,IL-36β,and IL-36γ(formerly IL-1F6,IL-1F8,and IL-1F9)are IL-1 family members that signal through the IL-1 receptor family members IL-1Rrp2(IL-1RL2)and IL-1RAcP.IL-36γ is secreted when transfected into 293-T cells and it could constitute part of an independent signaling system analogous to interleukin-1 alpha(IL-1A),beta(IL-1B)receptor agonist and interleukin-1 receptor type I(IL-1R1).Furthermore,IL-36γ also can function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2.Recombinant human IL-36γ is synthesized as a 19 kDa,169 amino acid(a.a.)protein that contains no signal sequence,no prosegment and no potential N-linked glycosylation site.Human to mouse,IL-36γ shares 53%a.a.identity.Within the family,IL-36γ shares about 25%~55%a.a.sequence identity with IL-1RA,IL-1β,IL-36RA,IL-36α,IL-37,IL-36β and IL-1F10.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组人IL-36γ(169a.a.)，IL-36γ, 169a.a., Human，Recombinant Human Interleukin-36 gamma, 169a.a.
储存条件：冷冻（-20℃）
概述
Interleukin-36(IL-36)is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases.IL-36α,IL-36β,and IL-36γ(formerly IL-1F6,IL-1F8,and IL-1F9)are IL-1 family members that signal through the IL-1 receptor family members IL-1Rrp2(IL-1RL2)and IL-1RAcP.IL-36γ is secreted when transfected into 293-T cells and it could constitute part of an independent signaling system analogous to interleukin-1 alpha(IL-1A),beta(IL-1B)receptor agonist and interleukin-1 receptor type I(IL-1R1).Furthermore,IL-36γ also can function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2.Recombinant human IL-36γ is synthesized as a 19 kDa,169 amino acid(a.a.)protein that contains no signal sequence,no prosegment and no potential N-linked glycosylation site.Human to mouse,IL-36γ shares 53%a.a.identity.Within the family,IL-36γ shares about 25%~55%a.a.sequence identity with IL-1RA,IL-1β,IL-36RA,IL-36α,IL-37,IL-36β and IL-1F10.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞95%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The specific activity is determined by its binding ability in a functional ELISA.Immobilized rHuIL-36γ at 1μg/mL can bind recombinant human IL-1 Rrp2 Fc Chimera with a range of 0.15-5 μg/mL. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4. |
| 内毒素 | Less than 1 EU/μg of rHuIL-36γ,169a.a.as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20?C.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | MRGTPGDADG GGRAVYQSMC KPITGTINDL NQQVWTLQGQ NLVAVPRSDS VTPVTVAVIT CKYPEALEQG RGDPIYLGIQ NPEMCLYCEK VGEQPTLQLK EQKIMDLYGQ PEPVKPFLFY RAKTGRTSTL ESVAFPDWFI ASSKRDQPII LTSELGKSYN TAFELNIND |
相关搜索：重组人IL-36γ(169a.a.)，IL-36γ, 169a.a., Human，Recombinant Human Interleukin-36 gamma, 169a.a.