产品货号：
GS4576
中文名称：
重组大鼠IL-21
英文名称：
Recombinant Rat Interleukin 21
产品规格：
2μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 15.2kDa,a single non-glycosylated polypeptide chain containing 129 amino acids.
储存条件：冷冻（-20℃）
概述
Rat IL-21 is produced by CD4+ T cells in response to antigenic stimulation and can regulating immune system cells,for instance cytotoxic T cells and natural killer cells.The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells,stimulation with IL-4 of IgG production,and induction of apoptotic effects in na?ve B-cells and stimulated B-cells in the absence of T-cell signaling.Additionally,it promotes the anti-tumor activity of CD8+ T-cells and NK cells.IL-21 elicits its effect through binding to IL-21R,which also contains the gamma chain found in other cytokine receptors such as IL-2,IL-4,IL-7,IL-9 and IL-15.IL-21 shows having much relation with clinical illnesses,including cancer immunotherapy,viral infections and allergies.Mature rat IL-21 shares 88%a.a.sequence identity with mouse IL-21.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组大鼠IL-21，IL-21, Rat，Recombinant Rat Interleukin 21
储存条件：冷冻（-20℃）
概述
Rat IL-21 is produced by CD4+ T cells in response to antigenic stimulation and can regulating immune system cells,for instance cytotoxic T cells and natural killer cells.The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells,stimulation with IL-4 of IgG production,and induction of apoptotic effects in na?ve B-cells and stimulated B-cells in the absence of T-cell signaling.Additionally,it promotes the anti-tumor activity of CD8+ T-cells and NK cells.IL-21 elicits its effect through binding to IL-21R,which also contains the gamma chain found in other cytokine receptors such as IL-2,IL-4,IL-7,IL-9 and IL-15.IL-21 shows having much relation with clinical illnesses,including cancer immunotherapy,viral infections and allergies.Mature rat IL-21 shares 88%a.a.sequence identity with mouse IL-21.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞96%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using human N1186 cells is less than 50ng/ml,corresponding to a specific activity of>2.0×104 IU/mg. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4. |
| 内毒素 | Less than 1 EU/μg of rRtIL-21 as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | HKSSPQRPDH LLIRLRHLMD IVEQLKIYEN DLDPELLTAP QDVKGQCEHE AFACFQKAKL KPSNTGNNKT FINDLLAQLR RRLPAKRTGN KQRHMAKCPS CDLYEKKTPK EFLERLKWLL QKMIHQHLS |
相关搜索：重组大鼠IL-21，IL-21, Rat，Recombinant Rat Interleukin 21