产品货号：
GS4478
中文名称：
重组人IL-12
英文名称：
Recombinant Human Interleukin-12
产品规格：
2μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 75kDa,consisting of a 306 amino acid residue p40 subunit and a 197 amino acid residue p35 subunit.
储存条件：冷冻（-20℃）
概述
Interleukin-12(IL-12),also known as NKSF or CLMF,is a pleiotropic cytokine originally identified in the medium of activated human B lymphoblastoid cell lines.The p40 subunit of IL-12 has been shown to have extensive amino acid sequence homology to the extracellular domain of the human IL-6 receptor while the p35 subunit shows distant but significant sequence similarity to IL-6,G-CSF,and chicken MGF.These observations have led to the suggestion that IL-12 might have evolved from a cytokine/soluble receptor complex.Human and murine IL-12 share 70%and 60%amino acid sequence homology in their p40 and p35 subunits,respectively.IL-12 apparently shows species specificity with human IL-12 reportedly showing minimal activity in the murine system.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组人IL-12，IL-12, Human，Recombinant Human Interleukin-12
储存条件：冷冻（-20℃）
概述
Interleukin-12(IL-12),also known as NKSF or CLMF,is a pleiotropic cytokine originally identified in the medium of activated human B lymphoblastoid cell lines.The p40 subunit of IL-12 has been shown to have extensive amino acid sequence homology to the extracellular domain of the human IL-6 receptor while the p35 subunit shows distant but significant sequence similarity to IL-6,G-CSF,and chicken MGF.These observations have led to the suggestion that IL-12 might have evolved from a cytokine/soluble receptor complex.Human and murine IL-12 share 70%and 60%amino acid sequence homology in their p40 and p35 subunits,respectively.IL-12 apparently shows species specificity with human IL-12 reportedly showing minimal activity in the murine system.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞95%by SDS-PAGE and HPLC analyses. |
| 来源 | CHO |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using PHA-activated human T lymphoblasts is less than 0.05ng/ml,corresponding to a specific activity of>2.0×107 IU/mg. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4. |
| 内毒素 | Less than 1 EU/μg of rHuIL-12 as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | p35 Subunit:RNLPVATPDP GMFPCLHHSQ NLLRAVSNML QKARQTLEFY PCTSEEIDHE DITKDKTSTV EACLPLELTK NESCLNSRET SFITNGSCLA SRKTSFMMAL CLSSIYEDLK MYQVEFKTMN AKLLMDPKRQ IFLDQNMLAV IDELMQALNF NSETVPQKSS LEEPDFYKTK IKLCILLHAF RIRAVTIDRV MSYLNAS；p40 Subunit:IWELKKDVYV |
相关搜索：重组人IL-12，IL-12, Human，Recombinant Human Interleukin-12