产品货号：
GS4473
中文名称：
重组小鼠IL-6
英文名称：
Recombinant Murine Interleukin-6
产品规格：
2μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 21.7kDa,a single non-glycosylated polypeptide chain containing 188 amino acids.
储存条件：冷冻（-20℃）
概述
Interleukin-6(IL-6)encoded by the IL-6 gene,acts as both a pro-inflammatory and anti-inflammatory cytokine.It is secreted by T cells and macrophages to stimulate immune response.It plays an essential role in the final differentiation of B-cells into Ig-secreting cells involved in lymphocyte and monocyte differentiation.It also induces myeloma and plasmacytoma growth and induces nerve cells differentiation acts on B-cells,T-cells,hepatocytes,hematopoietic progenitor cells and cells of the CNS.The mouse IL-6 is a single non-glycosylated polypeptide chain containing 187 amino acids and it signals through a cell-surface type I cytokine receptor complex consisting of the ligand-binding IL-6Rα chain(CD126),and the signal- transducing component gp130(also called CD130).The mouse IL-6 shares 40%and 85%a.a.sequence identity with human and rat IL-6 and it is equally active on human and rat cells.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组小鼠IL-6，IL-6, Murine，Recombinant Murine Interleukin-6
储存条件：冷冻（-20℃）
概述
Interleukin-6(IL-6)encoded by the IL-6 gene,acts as both a pro-inflammatory and anti-inflammatory cytokine.It is secreted by T cells and macrophages to stimulate immune response.It plays an essential role in the final differentiation of B-cells into Ig-secreting cells involved in lymphocyte and monocyte differentiation.It also induces myeloma and plasmacytoma growth and induces nerve cells differentiation acts on B-cells,T-cells,hepatocytes,hematopoietic progenitor cells and cells of the CNS.The mouse IL-6 is a single non-glycosylated polypeptide chain containing 187 amino acids and it signals through a cell-surface type I cytokine receptor complex consisting of the ligand-binding IL-6Rα chain(CD126),and the signal- transducing component gp130(also called CD130).The mouse IL-6 shares 40%and 85%a.a.sequence identity with human and rat IL-6 and it is equally active on human and rat cells.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞97%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by the dose-dependent stimulation of the proliferation of IL-6-dependent murine 7TD1 cells is less than 0.02ng/ml,corresponding to a specific activity of>5×107 IU/mg. |
| 成分 | Lyophilized from a 0.2μmfiltered solution in PBS,pH 7.4. |
| 内毒素 | Less than 1 EU/μg of rMuIL-6 as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | MFPTSQVRRG DFTEDTTPNR PVYTTSQVGG LITHVLWEIV EMRKELCNGN SDCMNNDDAL AENNLKLPEI QRNDGCYQTG YNQEICLLKI SSGLLEYHSY LEYMKNNLKD NKKDKARVLQ RDTETLIHIF NQEVKDLHKI VLPTPISNAL LTDKLESQKE WLRTKTIQFI LKSLEEFLKV TLRSTRQT |
相关搜索：重组小鼠IL-6，IL-6, Murine，Recombinant Murine Interleukin-6