产品货号：
GS4462
中文名称：
重组人IFN-λ1/IL-29
英文名称：
Recombinant Human Interferon-lambda1/Interleukin-29
产品规格：
5μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 19.8kDa,a single non-glycosylated polypeptide chain containing 181 amino acids.
储存条件：冷冻（-20℃）
概述
IL-28A,IL-28B,and IL-29,also named interferon-λ2(IFN-λ2),IFN-λ3,and IFN-λ1,respectively,are newly identified class II cytokine receptor ligands that are distantly related to members of the IL-10 family(11-13%a.a.sequence identity)and the type I IFN family(15-19%a.a.sequence identity).The expression of IL-28A,B,and IL-29 is induced by virus infection or double-stranded RNA.All three cytokines exert bioactivities that overlap those of type I IFNs,including antiviral activity and up-regulation of MHC class I antigen expression.The three proteins signal through the same heterodimeric receptor complex that is composed of the IL-10 receptor β(IL-10 Rβ)and a novel IL-28 receptor α(IL-28 Rα,also known as IFN-λR1).Ligand binding to the receptor complex induces Jak kinase activation and STAT1 and STAT2 tyrosine phosphorylation.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组人IFN-λ1/IL-29，IFN-λ1/IL-29, Human
储存条件：冷冻（-20℃）
概述
IL-28A,IL-28B,and IL-29,also named interferon-λ2(IFN-λ2),IFN-λ3,and IFN-λ1,respectively,are newly identified class II cytokine receptor ligands that are distantly related to members of the IL-10 family(11-13%a.a.sequence identity)and the type I IFN family(15-19%a.a.sequence identity).The expression of IL-28A,B,and IL-29 is induced by virus infection or double-stranded RNA.All three cytokines exert bioactivities that overlap those of type I IFNs,including antiviral activity and up-regulation of MHC class I antigen expression.The three proteins signal through the same heterodimeric receptor complex that is composed of the IL-10 receptor β(IL-10 Rβ)and a novel IL-28 receptor α(IL-28 Rα,also known as IFN-λR1).Ligand binding to the receptor complex induces Jak kinase activation and STAT1 and STAT2 tyrosine phosphorylation.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞97%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by an anti-viral assay using human HepG2 cells infected with encephalomyocarditis is less than 5ng/ml,corresponding to a specific activity of>2.0×105 IU/mg. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4. |
| 内毒素 | Less than 1 EU/μg of rHuIFN-λ1/IL-29 as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | GPVPTSKPTT TGKGCHIGRF KSLSPQELAS FKKARDALEE SLKLKNWSCS SPVFPGNWDL RLLQVRERPV ALEAELALTL KVLEAAAGPA LEDVLDQPLH TLHHILSQLQ ACIQPQPTAG PRPRGRLHHW LHRLQEAPKK ESAGCLEASV TFNLFRLLTR DLKYVADGNL CLRTSTHPES T |
相关搜索：重组人IFN-λ1/IL-29，IFN-λ1/IL-29, Human