产品货号：
GS4413
中文名称：
重组小鼠IFN-γ
英文名称：
Recombinant Murine Interferon-gamma
产品规格：
100μg
发货周期：
1～3天
产品价格：
询价
General Description：
Interferon-gamma (IFN-γ),also known as Type II interferon or immune interferon,is a cytokine produced primarily by T-lymphocytes and natural killer cells.The protein shares no significant homology with IFN-β or the various IFN-α family proteins.Mature IFN-γ exists as noncovalently-linked homodimers.It shares high sequence indentity with rat IFN-γ(86%).IFN-γ was originally characterized based on its antiviral activities.The protein also exerts antiproliferative,immunoregulatory and proinflammatory activities and is thus important in host defense mechanisms.IFN-γ induces the production of cytokines,upregulates the expression of class I and II MHC antigens,Fc receptor and leukocyte adhesion molecules.It modulates macrophage effector functions,influences isotype switching and potentiates the secretion of immunoglobulins by B cells.Additionally,IFN-γ augments TH1 cell expansion and may be required for TH1 cell differentiation.
Storage：
This lyophilized preparation is stable at 2～8℃,but should be kept at -20℃ for long term storage,preferably desiccated.Upon reconstitution,the preparation is stable for up to one week at 2～8℃.For maximal stability,apportion the reconstituted preparation into working aliquots and store at -20℃ to -70℃.Avoid repeated freeze/thaw cycles.
Usage：
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.
NOT FOR HUMAN USE.
Molecular Weight：
Approximately 15.5kDa,a single non-glycosylated polypeptide chain containing 133 amino acids.
Purity：
> 96% by SDS-PAGE and HPLC analyses.
Source：
Escherichia coli.
Biological Activity：
Fully biologically active when compared to standard.The ED50 as determined by an anti-viral assay using murine L929 cells infected with encephalomyocarditis (EMC) virus is less than 0.8ng/mL,corresponding to a specific activity of> 1.3×106 IU/mg.
Physical Appearance：
Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation：
Lyophilized from a 0.2μm filtered solution in 20mM Tris-HCl pH8.0,300mM NaCl,containing 5% trehalose,0.05% Tween-20.
Endotoxin：
Less than 1 EU/μg of rMuIFN-γ as determined by LAL method.
Reconstitution：
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled 20mM Tris-HCl pH8.0 with 50mM NaCl to a concentration of 0.1～0.3mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃.Further dilutions should be made in appropriate buffered solutions.
AA Sequence：
HGTVIESLES LNNYFNSSGI DVEEKSLFLD IWRNWQKDGD MKILQSQIIS FYLRLFEVLK DNQAISNNIS VIESHLITTF FSNSKAKKDA FMSIAKFEVN NPQVQRQAFN ELIRVVHQLL PESSLRKRKR SRC
Interferon-gamma (IFN-γ),also known as Type II interferon or immune interferon,is a cytokine produced primarily by T-lymphocytes and natural killer cells.The protein shares no significant homology with IFN-β or the various IFN-α family proteins.Mature IFN-γ exists as noncovalently-linked homodimers.It shares high sequence indentity with rat IFN-γ(86%).IFN-γ was originally characterized based on its antiviral activities.The protein also exerts antiproliferative,immunoregulatory and proinflammatory activities and is thus important in host defense mechanisms.IFN-γ induces the production of cytokines,upregulates the expression of class I and II MHC antigens,Fc receptor and leukocyte adhesion molecules.It modulates macrophage effector functions,influences isotype switching and potentiates the secretion of immunoglobulins by B cells.Additionally,IFN-γ augments TH1 cell expansion and may be required for TH1 cell differentiation.
Storage：
This lyophilized preparation is stable at 2～8℃,but should be kept at -20℃ for long term storage,preferably desiccated.Upon reconstitution,the preparation is stable for up to one week at 2～8℃.For maximal stability,apportion the reconstituted preparation into working aliquots and store at -20℃ to -70℃.Avoid repeated freeze/thaw cycles.
Usage：
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.
NOT FOR HUMAN USE.
Molecular Weight：
Approximately 15.5kDa,a single non-glycosylated polypeptide chain containing 133 amino acids.
Purity：
> 96% by SDS-PAGE and HPLC analyses.
Source：
Escherichia coli.
Biological Activity：
Fully biologically active when compared to standard.The ED50 as determined by an anti-viral assay using murine L929 cells infected with encephalomyocarditis (EMC) virus is less than 0.8ng/mL,corresponding to a specific activity of> 1.3×106 IU/mg.
Physical Appearance：
Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation：
Lyophilized from a 0.2μm filtered solution in 20mM Tris-HCl pH8.0,300mM NaCl,containing 5% trehalose,0.05% Tween-20.
Endotoxin：
Less than 1 EU/μg of rMuIFN-γ as determined by LAL method.
Reconstitution：
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled 20mM Tris-HCl pH8.0 with 50mM NaCl to a concentration of 0.1～0.3mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃.Further dilutions should be made in appropriate buffered solutions.
AA Sequence：
HGTVIESLES LNNYFNSSGI DVEEKSLFLD IWRNWQKDGD MKILQSQIIS FYLRLFEVLK DNQAISNNIS VIESHLITTF FSNSKAKKDA FMSIAKFEVN NPQVQRQAFN ELIRVVHQLL PESSLRKRKR SRC
相关搜索：重组小鼠IFN-γ，IFN-γ，Recombinant Murine Interferon-gamma