产品货号：
GS4405
中文名称：
重组小鼠IL-4
英文名称：
Recombinant Murine Interleukin-4
产品规格：
5μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 13.5kDa,a single non-glycosylated polypeptide chain containing 121 amino acids.
储存条件：冷冻（-20℃）
概述
Interleukin-4(IL-4)is a pleiotropic cytokine that induces differentiation of naive helper T cells(Th0 cells)to Th2 cells.It is produced by mast cells,activated T cells and bone marrow stromal cells.It has many biological roles,including the stimulation of activated B-cell and T-cell proliferation,and the differentiation of CD4+ T-cells into Th2 cells.IL-4 enhances both secretion and cell surface expression of IgE and IgG1 and also regulates the expression of the low affinity Fc receptor for IgE(CD23)on both lymphocytes and monocytes.The mouse IL-4 has a compact,globular fold,stabilised by 3 disulphide bonds and contains 121 amino acids residues which is a single non-glycosylated polypeptide.The human IL-4 shares about 40%a.a.sequence identity with mouse/rat IL-4 and they are species-specific in their activities.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组小鼠IL-4，IL-4, Murine，Recombinant Murine Interleukin-4
储存条件：冷冻（-20℃）
概述
Interleukin-4(IL-4)is a pleiotropic cytokine that induces differentiation of naive helper T cells(Th0 cells)to Th2 cells.It is produced by mast cells,activated T cells and bone marrow stromal cells.It has many biological roles,including the stimulation of activated B-cell and T-cell proliferation,and the differentiation of CD4+ T-cells into Th2 cells.IL-4 enhances both secretion and cell surface expression of IgE and IgG1 and also regulates the expression of the low affinity Fc receptor for IgE(CD23)on both lymphocytes and monocytes.The mouse IL-4 has a compact,globular fold,stabilised by 3 disulphide bonds and contains 121 amino acids residues which is a single non-glycosylated polypeptide.The human IL-4 shares about 40%a.a.sequence identity with mouse/rat IL-4 and they are species-specific in their activities.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞97%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by the dose-dependant prolifiration of Murine HT-2 cells is less then 2ng/ml,corresponding to a Specific Activity of>5×105 IU/mg. |
| 成分 | Lyophilized from a 0.2μmfiltered solution in PBS,pH 7.4. |
| 内毒素 | Less than 1 EU/μg of rMuIL-4 as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | MHIHGCDKNH LREIIGILNE VTGEGTPCTE MDVPNVLTAT KNTTESELVC RASKVLRIFY LKHGKTPCLK KNSSVLMELQ RLFRAFRCLD SSISCTMNES KSTSLKDFLE SLKSIMQMDY S |
相关搜索：重组小鼠IL-4，IL-4, Murine，Recombinant Murine Interleukin-4