产品货号：
Z39334
中文名称：
XIAP抗体
英文名称：
Anti-XIAP Antibody (Clone#1020CT7.2.2)
产品规格：
50μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-XIAP Antibody (Clone#1020CT7.2.2) |
| 指标别名 | API3;BIRC4;hIAP 3;hIAP3;hILP;IAP 3;IAP like protein;IAP3;ILP;ILP1;MIHA;X linked IAP;XIAP;XLP2 |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC,IF |
| 基因名称 | XIAP |
| 克隆号 | 1020CT7.2.2 |
| 抗体来源 | Mouse |
| 免疫原 | This XIAP antibody is generated from a mouse immunized with a recombinant protein human XIAP. |
| 计算分子量 | 57kDa |
| 成分 | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein G column,followed by dialysis against PBS |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Multi-functional protein which regulates not only caspases and apoptosis,but also modulates inflammatory signaling and immunity,copper homeostasis,mitogenic kinase signaling,cell proliferation,as well as cell invasion and metastasis.Acts as a direct caspase inhibitor.Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry.Inactivates CASP9 by keeping it in a monomeric,inactive state.Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include:RIPK1,CASP3,CASP7,CASP8,CASP9,MAP3K2/MEKK2,DIABLO/SMAC,AIFM1,CCS and BIRC5/survivin.Ubiquitinion of CCS leads to enhancement of its chaperone activity toward its physiologic target,SOD1,rather than proteasomal degradation.Ubiquitinion of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation.Plays a role in copper homeostasis by ubiquitinationg COMMD1 and promoting its proteasomal degradation.Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway,targeting effector caspases for neddylation and inactivation.Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation.Acts as an important regulator of innate immune signaling via regulation of Nodlike receptors (NLRs).Protects cells from spontaneous formation of the ripoptosome,a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner.Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1,TLE2,TLE3,TLE4 and AES.Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta- catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program. |
| Uniprot ID | P98170 |
相关搜索：XIAP抗体，XIAP单抗，Anti-XIAP Antibody (Clone#1020CT7.2.2)