产品货号：
Z39096
中文名称：
Transferrin/TF Purified Azide Free抗体
英文名称：
Anti-Transferrin/TF Purified Azide Free Antibody (Clone#HTF-14)
产品规格：
0.1mg(C100)
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Transferrin/TF Purified Azide Free Antibody (Clone#HTF-14) |
| 指标别名 | Beta 1 metal binding globulin;PRO1557;PRO2086;Serotransferrin;Siderophilin;TF;Transferrin |
| 克隆性 | Monoclonal |
| 检验物种 | human,pig,rabbit |
| 应用范围 | WB,IHC,ICC,ELISA,RIA,Functional Assay |
| 基因名称 | TF |
| 克隆号 | HTF-14 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG1 |
| 免疫原 | Purified porcine transferrin.The antibody HTF-14 recognizes an epitope located in the N-terminal domain of human serum transferrin,a 77kDa single polypeptide chain glycoprotein (member of the iron binding family of proteins).It is synthesised in the liver and consists of two domains each having a high affinity reversible binding site for Fe3+. |
| 计算分子量 | 77kDa |
| 成分 | Phosphate buffered saline (PBS),pH7.4,azide-free |
| 纯化方式 | Purified by protein-A affinity chromatography. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | Store at 2～8℃.Do not freeze. |
| 背景资料 | Transferrin is a monomeric glycoprotein of approximately 77kDa,which serves as an iron-transporter.In normal plasma,transferrin has a concentration of 25-50μmol/liter,and is usually about one-third saturated with iron,thus providing a large buffering capacity in case of an acute increase in plasma iron levels.Cells take up transferrin-iron complexes (holotransferrin) using transferrin receptor dimers.Upon binding of holotransferrin,the receptor is internalized by clathrin-mediated endocytosis.Acidification of endosomes by vesicular membrane proton pumps leads to dissociation of iron ions,whereas transferrin (apotransferrin) remains associated with its receptor (CD71) and recycles to the cell surface,where apotransferrin is released upon exposure to normal pH.Internalization of labeled transferrin thus represents an usefull approach to study endocytosis.Serum concentration rises in iron deficiency and pregnancy and falls in iron overload,infection and inflammatory conditions.Iron/transferrin complex is essential in haemoglobin synthesis and for certain types of cell division. |
| Uniprot ID | P02787 |
| 基因名全称 | Transferrin |
| 蛋白名全称 | Serotransferrin |
| 推荐稀释比 | Functional application:The antibody HTF-14 blocks binding of transferrin to its receptor. Immunohistochemistry (paraffin sections):10μg/mL;positive tissue:placenta. Western blotting:non-reducing conditions,recommended dilution:1～2μg/mL. |
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