产品货号：
Z39060
中文名称：
VEGFR3/FLT4抗体
英文名称：
Anti-VEGFR3/FLT4 Antibody (Clone#818CT12.1.1)
产品规格：
80μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-VEGFR3/FLT4 Antibody (Clone#818CT12.1.1) |
| 指标别名 | FLT 4;FLT4;FLT41;Fms like tyrosine kinase 4;fms related tyrosine kinase 4;LMPH1A;PCL;VEGFR 3;VEGFR3 |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | IHC,FCM,WB |
| 基因名称 | FLT4 |
| 克隆号 | 818CT12.1.1 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG2a |
| 免疫原 | Purified His-tagged VEGFR3 protein was used to produced this monoclonal antibody. |
| 计算分子量 | 153kDa |
| 成分 | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein G column,followed by dialysis against PBS |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD,and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development.Promotes proliferation,survival and migration of endothelial cells,and regulates angiogenic sprouting.Signaling by activated FLT4 leads to enhanced production of VEGFC,and to a lesser degree VEGFA,thereby creating a positive feedback loop that enhances FLT4 signaling.Modulates KDR signaling by forming heterodimers.The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis.Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades;isoform 2 seems to be less efficient in signal transduction,because it has a truncated C-terminus and therefore lacks several phosphorylation sites.Mediates activation of the MAPK1/ERK2,MAPK3/ERK1 signaling pathway,of MAPK8 and the JUN signaling pathway,and of the AKT1 signaling pathway.Phosphorylates SHC1.Mediates phosphorylation of PIK3R1,the regulatory subunit of phosphatidylinositol 3-kinase.Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185',and of AKT1 at 'Ser-473'. |
| Uniprot ID | P35916 |
相关搜索：VEGFR3/FLT4抗体，VEGFR3抗体，FLT4单抗，Anti-VEGFR3/FLT4 Antibody (Clone#818CT12.1.1)