产品货号：
Z39056
中文名称：
VEGFR1/FLT1抗体
英文名称：
Anti-VEGFR1/FLT1 Antibody (Clone#1453CT519.277.79)
产品规格：
80μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-VEGFR1/FLT1 Antibody (Clone#1453CT519.277.79) |
| 指标别名 | FLT;FLT 1;FLT1;FLT-1;Fms like tyrosine kinase 1;FRT;sflt1;Tyrosine protein kinase FRT;VEGF receptor 1;VEGFR 1;VEGFR1;VEGFR-1;VEGFR-1/FLT-1 |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB |
| 基因名称 | FLT1 |
| 克隆号 | 1453CT519.277.79 |
| 抗体来源 | Mouse |
| 免疫原 | This FLT1 antibody is generated from a mouse immunized with a recombinant protein. |
| 计算分子量 | 151kDa |
| 成分 | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein G column,followed by dialysis against PBS |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA,VEGFB and PGF,and plays an essential role in the development of embryonic vasculature,the regulation of angiogenesis,cell survival,cell migration,macrophage function,chemotaxis,and cancer cell invasion.May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells.Can promote endothelial cell proliferation,survival and angiogenesis in adulthood.Its function in promoting cell proliferation seems to be cell-type specific.Promotes PGF-mediated proliferation of endothelial cells,proliferation of some types of cancer cells,but does not promote proliferation of normal fibroblasts (in vitro).Has very high affinity for VEGFA and relatively low protein kinase activity;may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR.Likewise,isoforms lacking a transmembrane domain,such as isoform 2,isoform 3 and isoform 4,may function as decoy receptors for VEGFA.Modulates KDR signaling by forming heterodimers with KDR.Ligand binding leads to the activation of several signaling cascades.Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C.Mediates phosphorylation of PIK3R1,the regulatory subunit of phosphatidylinositol 3-kinase,leading to activation of phosphatidylinositol kinase and the downstream signaling pathway.Mediates activation of MAPK1/ERK2,MAPK3/ERK1 and the MAP kinase signaling pathway,as well as of the AKT1 signaling pathway.Phosphorylates SRC and YES1,and may also phosphorylate CBL.Isoform 1 phosphorylates PLCG.Promotes phosphorylation of AKT1 at 'Ser-473'.Promotes phosphorylation of PTK2/FAK1.Isoform 7 has a truncated kinase domain;it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion. |
| Uniprot ID | P17948 |
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