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产品目录

所在位置:所有产品 > 抗体抗原 > 一抗 > SHC/SHC1抗体
SHC/SHC1抗体图片
产品货号:
Z38931
中文名称:
SHC/SHC1抗体
英文名称:
Anti-SHC/SHC1 Antibody (Clone#OTI3A1)
产品规格:
50μl|100μl|150μl
发货周期:
1~3天
产品价格:
询价
抗体名称Anti-SHC/SHC1 Antibody (Clone#OTI3A1)
指标别名SH2 domain protein C1;SHC;SHC transforming protein 1;SHC transforming protein 3;SHC transforming protein A;SHC1;SHCA
克隆性Monoclonal
检验物种human,mouse,rat
应用范围WB,IHC,IF
基因名称SHC1
克隆号OTI3A1
抗体来源Mouse
抗体类型IgG1
免疫原Full length human recombinant protein of human SHC1 (NP_003020) produced in HEK293T cell.
实际分子量51.5KD
成分PBS (PH 7.3) containing 1% BSA,50% glycerol and 0.02% sodium azide.
纯化方式Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
浓度500μg/mL
产品形态溶液
保存条件Stable for 12 months from date of receipt.Store at -20℃ as received.
背景资料Signaling adapter that couples activated growth factor receptors to signaling pathway.Isoform p46Shc and isoform p52Shc,once phosphorylated,couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals.Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems.Isoform p66Shc does not mediate Ras activation,but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span.Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants,cytochrome c release and apoptosis.The expression of isoform p66Shc has been correlated with life span
Uniprot IDP29353
基因名全称SHC (Src homology 2 domain containing) transforming protein 1
蛋白名全称SHC-transforming protein 1
推荐稀释比
Western blot (WB) 1:2000
Immunohistochemistry in paraffin section (IHC) 1:50
Immunofluorescence (IF) 1:100

相关搜索:SHC/SHC1抗体SHC抗体SHC1单抗Anti-SHC/SHC1 Antibody (Clone#OTI3A1)
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