产品货号：
Z38799
中文名称：
YES1-Specific抗体
英文名称：
Anti-YES1-Specific Antibody (Clone#1612CT505.7.50)
产品规格：
50μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-YES1-Specific Antibody (Clone#1612CT505.7.50) |
| 指标别名 | c yes;HsT441;P61 YES;Proto oncogene c Yes;Yes;YES1;YES1-Specific |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB |
| 基因名称 | YES1 |
| 克隆号 | 1612CT505.7.50 |
| 抗体来源 | Mouse |
| 免疫原 | This YES1 antibody is generated from a mouse immunized with a recombinant protein of human YES1. |
| 计算分子量 | 61kDa |
| 成分 | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein G column,followed by dialysis against PBS |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival,apoptosis,cell-cell adhesion,cytoskeleton remodeling,and differentiation.Stimulation by receptor tyrosine kinases (RTKs) including EGRF,PDGFR,CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor,and activation and phosphorylation of downstream substrates.Upon EGFR activation,promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly.Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts.Upon T-cell stimulation by CXCL12,phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration.Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration.Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase.Also involved in G2/M progression and cytokinesis. |
| Uniprot ID | P07947 |
相关搜索：YES1-Specific抗体，YES1-Specific单抗