产品货号：
Z38554
中文名称：
TRIB3抗体
英文名称：
Anti-TRIB3 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-TRIB3 Antibody |
| 指标别名 | C20orf97;NIPK;SINK;SKIP3;TRB 3;TRB3;TRIB3;Tribbles homolog 3 |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB |
| 基因名称 | TRIB3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human TRIB3 Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation.May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1.Binds to ATF4 and inhibits its transcriptional activation activity.Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. |
| 实际分子量 | 40KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | TRIBBLES proteins belong to a small family of serine-threonine kinase-like proteins characterized by the presence of a variant protein kinase motif (lacking a canonical ATP binding site),a MEK-1 binding site,and a C-terminal COP1 site that binds ubiquitin ligase.The tribbles gene was first identified and characterized in Drosophila genetic screens for genes that regulate cell division,gastrulation,and oogenesis (1-3).Research studies in Drosophila suggested that TRIBBLES functions to coordinate cell division by regulating turnover of the cell cycle protein String/cdc25.In contrast to the Drosophila genome,which contains a single tribbles gene,the genomes of mice and humans encode three known TRIBBLES proteins (TRIB1-3),which exhibit both distinct and overlapping patterns of expression and functions (4).For example,TRIB1 and TRIB2,but not TRIB3,were reported to promote degradation of the basic region-leucine zipper transcription factor C/EBPα,a function that appears to be conserved from flies to humans (5,6).TRIB2 is overexpressed in a subset of human AML patient samples,downregulated in leukemic cells undergoing proliferation arrest (7),and positively regulated by the NOTCH signaling pathway in T cells (8),while retroviral-mediated overexpression of TRIB2 in mice was shown to induce transplantable leukemia (7).These findings collectively suggest that TRIB2 functions as an oncogene in the mammalian hematopoietic system (9). |
| Uniprot ID | Q96RU7 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 |
相关搜索：TRIB3抗体，TRIB3单抗，Anti-TRIB3 Antibody