产品货号：
Z37815
中文名称：
G-CSFR/CSF3R抗体
英文名称：
Anti-G-CSFR/CSF3R Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-G-CSFR/CSF3R Antibody |
| 指标别名 | CD114;CSF3R;G CSF R;G CSF receptor;GCSFR;G-CSFR;G-CSF-R |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB,FCM |
| 基因名称 | CSF3R |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human GCSF Receptor (CD114) Receptor for granulocyte colony-stimulating factor (CSF3),essential for granulocytic maturation.Plays a crucial role in the proliferation,differientation and survival of cells along the neutrophilic lineage.In addition it may function in some adhesion or recognition events at the cell surface. |
| 实际分子量 | 95KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | CSF3R(Colony-Stimulating Factor 3 Receptor,Granulocyte) also known as GCSFR or CD114((Cluster of Differentiation 114) is a protein that in humans is encoded by the CSF3R gene.G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor(G-CSF).The G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family.The CSF3R gene consists of 17 exons.By in situ hybridization using human CSF3R cDNA as a probe,Inazawa et al.(1991) localized the gene to 1p35-p34.3.The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion,a transmembrane domain,and the cytoplasmic portion that is responsible for signal transduction.GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak,Lyn,STAT,and Erk1/2.Dong et al.(2001) reported that the C terminus of CSF3R is required for SHP1 downregulation of CSF3-induced STAT activation.The authors proposed that this mechanism inhibits cell proliferation and survival in response to CSF3. |
| Uniprot ID | Q99062 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Flow cytometry (FCM) 1:20 |
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