产品货号：
Z37755
中文名称：
Hu CD45/PTPRC Purified抗体
英文名称：
Anti-Hu CD45/PTPRC Purified Antibody (Clone#MEM-28)
产品规格：
0.1mg(C100)
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Hu CD45/PTPRC Purified Antibody (Clone#MEM-28) |
| 指标别名 | B220;CD45;CD45R;GP180;L CA;LCA;Leukocyte common antigen;LY5;PTPRC;RPTPC;T200 |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | FCM,IP,WB,IHC,ICC |
| 基因名称 | PTPRC |
| 克隆号 | MEM-28 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG1 |
| 免疫原 | Human thymocytes and T lymphocytes.The antibody MEM-28 reacts with an extracellular epitope on all alternative forms of human CD45 antigen (Leukocyte Common Antigen),a 180～220kDa single chain type I transmembrane protein expressed at high level on all cells of hematopoietic origin,except erythrocytes and platelets. |
| 计算分子量 | 147kDa |
| 成分 | Phosphate buffered saline (PBS),pH7.4,15mM sodium azide |
| 纯化方式 | Purified by protein-A affinity chromatography. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | Store at 2～8℃.Do not freeze. |
| 背景资料 | CD45 (LCA,leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells,comprising approximately 10% of all surface proteins in lymphocytes.CD45 glycoprotein is crucial in lymphocyte development and antigen signaling,serving as an important regulator of Src-family kinases.CD45 protein exists as multiple isoforms as a result of alternative splicing;these isoforms differ in their extracellular domains,whereas they share identical transmembrane and cytoplasmic domains.These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell.Besides the role in immunoreceptor signaling,CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. |
| Uniprot ID | P08575 |
| 基因名全称 | Protein tyrosine phosphatase receptor type C |
| 蛋白名全称 | Receptor-type tyrosine-protein phosphatase C |
| 推荐稀释比 | Immunohistochemistry (paraffin sections):No pre-treatment of tissue sections is needed. Immunocytochemistry:10μg/mL;paraformaldehyde fixation can be used. Western blotting:1μg/mL;non-reducing conditions,band around 200～250kDa;positive control:JURKAT human leukemia T-cell lysate,Kg-1a human leukemia cell lysate;non-reducing conditions,6% separating gel. Flow cytometry:1μg/mL. |
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