产品货号：
Z37754
中文名称：
Hu CD47 Purified抗体
英文名称：
Anti-Hu CD47 Purified Antibody (Clone#MEM-122)
产品规格：
0.1mg(C100)
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Hu CD47 Purified Antibody (Clone#MEM-122) |
| 指标别名 | CD47;CD47 molecule;IAP;Leukocyte surface antigen CD47;MER6;OA3;Protein MER6 |
| 克隆性 | Monoclonal |
| 检验物种 | primate,human,pig |
| 应用范围 | FCM,WB,IHC-F |
| 基因名称 | CD47 |
| 克隆号 | MEM-122 |
| 抗体来源 | Mouse |
| 抗体类型 | IgM |
| 免疫原 | COS-7 (African green monkey) cells.The antibody MEM-122 reacts with an extracellular epitope of CD47 (Integrin Associated Protein),a 50～55kDa membrane adhesion molecule (thrombospondin receptor;immunoglobulin supergene family) expressed on leukocytes,platelets and erythrocytes.It is also expressed on epithelial cells,endothelial cells,fibroblasts and many tumor cell lines. |
| 计算分子量 | 35kDa |
| 成分 | Tris buffered saline (TBS),pH8.0,15mM sodium azide |
| 纯化方式 | Purified by sequential steps of physicochemical fractionation (differential precipitation and solid-phase chromatography methods). |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | Store at 2～8℃.Do not freeze. |
| 背景资料 | CD47 (integrin-associated protein,IAP) is an ubiquitously expressed cell surface transmembrane glycoprotein interacting with several integrins and regulating their functions.Engagement of CD47 by soluble ligands or counter receptors modulates various signaling pathways,such as activation of heterotrimeric G proteins.Binding secreted thrombospondin-1,CD47 counteracts graft vascularization.CD47 acts also as a ligand for CD172a (signal regulatory protein alpha,SIRP alpha),an immune inhibitory receptor on macrophages;this interaction prevents phagocytosis of CD47-positive cells.Moreover,CD47-CD172a system affects cell migration,B cell adhesion and T cell activation.CD47 is also involved in modulation of chondrocyte responses to mechanical signals,and promotes neuronal development,being especially abundant in synapse-rich regions of brain and retina. |
| Uniprot ID | Q08722 |
| 基因名全称 | CD47 molecule |
| 蛋白名全称 | Leukocyte surface antigen CD47 |
| 推荐稀释比 | Flow cytometry:2μg/mL. Western blotting:Non-reducing conditions. |
相关搜索：Hu CD47 Purified抗体，Hu CD47 Purified单抗，Anti-Hu CD47 Purified Antibody (Clone#MEM-122)