产品货号：
Z37415
中文名称：
IRAK4抗体
英文名称：
Anti-IRAK4 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-IRAK4 Antibody |
| 指标别名 | IPD1;IRAK 4;IRAK4;NY REN 64;REN64 |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC,ICC/IF,FCM |
| 基因名称 | IRAK4 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human IRAK4 Required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement,triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.Phosphorylates IRAK1. |
| 实际分子量 | 52KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | IRAK-4(interleukin-1 receptor-associated kinase 4),also called REN64,in the IRAK family,is a protein kinase involved in signaling innate immune responses from Toll-like receptors.It also supports signaling from T-cell receptors.Scott(2002) mapped the REN64/IRAK4 gene to chromosome 12 based on similarity between the REN64 sequence(GenBank AF155118) and a chromosome 12 clone(GenBank AC093012).Functional analysis by Li et al.(2002) determined that IRAK4,like IRAK1 and Pelle,has auto- and cross-phosphorylation kinase activity.Precipitation and binding analyses showed weak interaction between IRAK4 and IRAK1,but IRAK4 did not interact with other IRAK family members.Overexpressed IRAK4 interacted with MYD88 and TRAF6 and activated mitogen-activated protein kinase(MAPK) and nuclear factor kappa-B(NFKB) pathways. |
| Uniprot ID | Q9NWZ3 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:20～100ICC/IF 1:50～1:200 FC 1:50 |
相关搜索：IRAK4抗体，IRAK4单抗，Anti-IRAK4 Antibody