产品货号：
Z37315
中文名称：
JAB1/COPS5抗体
英文名称：
Anti-JAB1/COPS5 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-JAB1/COPS5 Antibody |
| 指标别名 | COPS5;CSN5;JAB1;MOV 34;SGN5;Signalosome subunit 5 |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | COPS5 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human JAB1 Probable protease subunit of the COP9 signalosome complex (CSN),a complex involved in various cellular and developmental processes.The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes,leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF,CSA or DDB2. |
| 实际分子量 | 38KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis),also known as COPS5 or JAB1,is a gene conserved from humans to Saccharomyces cerevisiae.It is a member of the MOV34 family.COPS5 is mapped to 8q13.1.The protein encoded by this gene is one of the eight subunits of COP9 signalosome,a highly conserved protein complex that functions as an important regulator in multiple signaling pathways.COPS5 can interact with the cytoplasmic domain of the beta-2 subunit of the alpha-L/beta-2 integrin LFA1,and it is the only protein demonstrated to interact with MIF.COPS5,VHL,and TRC8 proteins appear to be linked both physically and functionally,and all 3 may participate in the development of kidney cancer.In addition to that,COPS5 is an essential cofactor for the apoptotic function of E2F1. |
| Uniprot ID | Q92905 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 |
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