产品货号：
Z37215
中文名称：
Hu CD18/ITGB2 Purified抗体
英文名称：
Anti-Hu CD18/ITGB2 Purified Antibody (Clone#MEM-48)
产品规格：
0.1mg(C100)
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Hu CD18/ITGB2 Purified Antibody (Clone#MEM-48) |
| 指标别名 | CD18;Integrin beta 2;ITGB2;LAD;LCAMB;LFA 1;MAC 1;MF17;MFI7 |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | FCM,IP,WB,IHC,IHC-F |
| 基因名称 | ITGB2 |
| 克隆号 | MEM-48 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG1 |
| 免疫原 | Leukocytes of a patient suffering from a LGL-type leukemia.The antibody MEM-48 recognizes an extracellular epitope involving residues 534-546 in cysteine-rich repeat 3 of the CD18 antigen (integrin beta2 subunit;beta2 integrin).CD18 is a 90～95kDa type I transmembrane protein expressed on all leukocytes. |
| 计算分子量 | 85kDa |
| 成分 | Phosphate buffered saline (PBS),pH7.4,15mM sodium azide |
| 纯化方式 | Purified by sequential steps of physicochemical fractionation (differential precipitation and solid-phase chromatography methods). |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | Store at 2～8℃.Do not freeze. |
| 背景资料 | CD18,integrin beta2 subunit,forms heterodimers with four types of CD11 molecule to constitute leukocyte (beta2) integrins:alphaLbeta2 (CD11a/CD18,LFA-1),alphaMbeta2 (CD11b/CD18,Mac-1,CR3),alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18).In most cases,the response mediated by the integrin is a composite of the functions of its individual subunits.These integrins are essential for proper leukocyte migration,mediating intercellular contacts.Absence of CD18 leads to leukocyte adhesion deficiency-1;severe reduction of CD18 expression leads to the development of a psoriasiform skin disease.CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis. |
| Uniprot ID | P05107 |
| 基因名全称 | Integrin subunit beta 2 |
| 蛋白名全称 | Integrin beta-2 |
| 推荐稀释比 | Western blotting:2μg/mL;positive control:Kg-1a human leukemia cell lysate,non-reducing conditions. Flow cytometry:2μg/mL. Immunohistochemistry (paraffin sections):10μg/mL;positive tissue:spleen,microglia. |
相关搜索：Hu CD18/ITGB2 Purified抗体，Hu CD18抗体，ITGB2 Purified单抗