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产品目录

PKR/EIF2AK2抗体图片
产品货号:
Z37195
中文名称:
PKR/EIF2AK2抗体
英文名称:
Anti-PKR/EIF2AK2 Antibody
产品规格:
50μl|100μl|150μl
发货周期:
1~3天
产品价格:
询价
抗体名称Anti-PKR/EIF2AK2 Antibody
指标别名eIF 2A protein kinase 2;EIF2AK1;EIF2AK2;P1/eIF 2A protein kinase;p68 kinase;PKR;PRKR;Protein kinase RNA activated
克隆性Monoclonal
检验物种human
应用范围WB,IHC,ICC/IF,IP
基因名称EIF2AK2
抗体来源Rabbit
抗体类型IgG
免疫原A synthesized peptide derived from human PKR
实际分子量69KD
成分500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol.
纯化方式Affinity-chromatography
浓度500μg/mL
产品形态溶液
保存条件12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing.
背景资料EIF2AK2(Eukaryotic Translation Initiation Factor 2-Alpha Kinase 2),also called PKR,is an enzyme that in humans is encoded by the EIF2AK2 gene.Activation of EIF2AK2 allows the kinase to phosphorylate its natural substrate,the alpha subunit of eukaryotic protein synthesis initiation factor-2,leading to the inhibition of protein synthesis(summary by Kuhen et al.,1996).By FISH analysis,Squire et al.(1993) assigned the EIF2AK2 gene to the boundary between chromosome 2p22-p21.Ben-Asouli et al.(2002) showed that human gamma-interferon mRNA uses local activation of PKR in the cell to control its own translation yield.IFNG mRNA was found to activate PKR through a pseudoknot in its 5-prime untranslated region.Taylor et al.(1999) studied the mechanism underlying the resistance of hepatitis C virus(HCV) to interferon.They demonstrated that the HCV envelope protein E2 contains a sequence identical with phosphorylation sites of the interferon-inducible protein kinase PKR and the translation initiation factor EIF2-alpha,a target of PKR.E2 inhibited the kinase activity of PKR and blocked its inhibitory effect on protein synthesis and cell growth.
Uniprot IDP19525
基因名全称Interferon-induced,double-stranded RNA-activated protein kinase
推荐稀释比
Western blot (WB) 1:1000~5000
Immunohistochemistry in paraffin section (IHC) 1:20~100
Immunocytochemistry/Immunofluorescence(ICC/IF) 1:20~100
Immunocoprecipitation 1:20

相关搜索:PKR/EIF2AK2抗体PKR抗体EIF2AK2单抗Anti-PKR/EIF2AK2 Antibody
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