产品货号：
Z36838
中文名称：
Raptor/RPTOR抗体
英文名称：
Anti-Raptor/RPTOR Antibody (Clone#1411CT316.2.151.34)
产品规格：
80μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Raptor/RPTOR Antibody (Clone#1411CT316.2.151.34) |
| 指标别名 | KIAA1303;raptor;RPTOR |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | IHC,WB |
| 基因名称 | RPTOR |
| 克隆号 | 1411CT316.2.151.34 |
| 抗体来源 | Mouse |
| 免疫原 | This RPTOR antibody is generated from a mouse immunized with recombinant protein. |
| 计算分子量 | 149kDa |
| 成分 | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein G column,followed by dialysis against PBS |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival,and autophagy in response to nutrient and hormonal signals;functions as a scaffold for recruiting mTORC1 substrates.mTORC1 is activated in response to growth factors or amino acids.Growth factor-stimulated mTORC1 activation involves a AKT1- mediated phosphorylation of TSC1-TSC2,which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1.Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases.Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis.mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E).mTORC1 phosphorylates and activates S6K1 at 'Thr-389',which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation.Involved in ciliogenesis. |
| Uniprot ID | Q8N122 |
相关搜索：Raptor/RPTOR抗体，Raptor抗体，RPTOR单抗