产品货号：
Z36815
中文名称：
RBX1抗体
英文名称：
Anti-RBX1 Antibody (Clone#1859CT866.7.47)
产品规格：
50μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-RBX1 Antibody (Clone#1859CT866.7.47) |
| 指标别名 | Protein ZYP;RBX1;Regulator of cullins 1;ring box 1;RING box protein 1;RING finger protein 75;RNF75;ROC1 |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse |
| 应用范围 | WB |
| 基因名称 | RBX1 |
| 克隆号 | 1859CT866.7.47 |
| 抗体来源 | Mouse |
| 免疫原 | This antibody is generated from a mouse immunized with a recombinant protein between 1-108 amino acids from human. |
| 计算分子量 | 12kDa |
| 成分 | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein G column,followed by dialysis against PBS |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | E3 ubiquitin ligase component of multiple cullin-RING- based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins,including proteins involved in cell cycle progression,signal transduction,transcription and transcription-coupled nucleotide excision repair.The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components.As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation.Through the RING-type zinc finger,seems to recruit the E2 ubiquitination enzyme,like CDC34,to the complex and brings it into close proximity to the substrate.Probably also stimulates CDC34 autoubiquitination.May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair.Promotes the neddylation of CUL1,CUL2,CUL4 and CUL4 via its interaction with UBE2M.Involved in the ubiquitination of KEAP1,ENC1 and KLHL41.In concert with ATF2 and CUL3,promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. |
| Uniprot ID | P62877 |
相关搜索：RBX1抗体，RBX1单抗，Anti-RBX1 Antibody (Clone#1859CT866.7.47)