产品货号：
Z36793
中文名称：
PUMA/BBC3抗体
英文名称：
Anti-PUMA/BBC3 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PUMA/BBC3 Antibody |
| 指标别名 | BBC3;JFY 1;JFY1;PUMA |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF,FCM |
| 基因名称 | BBC3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human PUMA |
| 实际分子量 | 21KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | The p53 upregulated modulator of apoptosis,or PUMA,is a pro-apoptotic member of the Bcl-2 protein family.The PUMA gene is located at 19q.PUMA transcript is contained within 4 exons,with the presumptive initiation codon in exon 2.The predicted 193-amino acid PUMA protein shares 91% amino acid identity with the murine sequence.Bcl-2 family members can form hetero- or homodimers,and they act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities.The expression of PUMA is regulated by the tumor suppressor p53,and PUMA has been shown to be involved in p53-mediated apoptosis.Additionally,PUMA encodes 2 BH3 domain-containing proteins,PUMA-alpha and PUMA-beta,that are produced through the use of an alternative first exon and are induced in cells following p53 activation.Furthermore,PUMA couples the nuclear and cytoplasmic proapoptotic functions of p53. |
| Uniprot ID | Q9BXH1 |
| 基因名全称 | Bcl-2-binding component 3 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:20～100ICC/IF 1:50～1:200 FC 1:50 |
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