产品货号：
Z36783
中文名称：
PARN抗体
英文名称：
Anti-PARN Antibody (Clone#11D8)
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PARN Antibody (Clone#11D8) |
| 指标别名 | DAN;Deadenylating nuclease;Deadenylation nuclease;PARN |
| 克隆性 | Monoclonal |
| 检验物种 | human,monkey,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF,FCM |
| 基因名称 | PARN |
| 克隆号 | 11D8 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG2b |
| 免疫原 | E.coli-derived human PARN recombinant protein (Position:M1-Y301). |
| 实际分子量 | 78KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | protein G purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Poly(A)-specific ribonuclease (PARN),also known as polyadenylate-specific ribonuclease or deadenylating nuclease (DAN),is an enzyme that in humans is encoded by the PARN gene.The protein encoded by this gene is a 3'-exoribonuclease,with similarity to the RNase D family of 3'-exonucleases.It prefers poly(A) as the substrate,hence,efficiently degrades poly(A) tails of mRNAs.Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs.This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development,as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. |
| Uniprot ID | O95453 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-mouse IgG (ZN1928) for Western blot,and HRP Conjugated anti-mouse IgG Super Vision Assay Kit (ZN1866) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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