产品货号：
Z36775
中文名称：
PARD6A抗体
英文名称：
Anti-PARD6A Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PARD6A Antibody |
| 指标别名 | par-6 family cell polarity regulator alpha;PAR-6A;PAR6;PAR6C;PAR6alpha;TAX40;TIP-40;PARD6A |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | PARD6A |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human PAR6 Adapter protein involved in asymmetrical cell division and cell polarization processes.Probably involved in the formation of epithelial tight junctions.Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1,thereby preventing tight junction assembly. |
| 实际分子量 | 37KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Cellular asymmetry is critical for the development of multicellular organisms.PARD (partitioning-defective) proteins play important roles in asymmetric cell division and polarized growth,whereas Cdc42 and Rac mediate establishment of cell growth and polarity and contribute to oncogenic transformation by Ras.The human PARD6,a 345 amino acid polypeptide,has a PDZ domain and a CRIB-like (Cdc42/Rac interactive binding) motif.PARD6 interacts with GTPbound Rac and Cdc42 via this motif and with the atypical PKC isoforms PKCi/l and PKCz via N-terminal head to head association.These interactions allow formation of a ternary complex in vitro and in vivo,which is implicated in the formation of normal tight junctions at epithelial cell-cell contacts and is also involved in the polarization of mother cells before asymmetric cell division in C.elegans.PARD6 acts through PARD3 by localizing or maintaining the PARD3 protein at the cell periphery.PARD6A,also designated PAR-6a,PAR6C,TAX40 and TIP-40,is expressed in pancreas,skeletal muscle,brain and heart,and is weakly expressed in kidney and placenta.PAR6B is expressed in pancreas and in both adult and fetal kidney,and is weakly expressed in placenta and lung. |
| Uniprot ID | Q9NPB6 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 |
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