产品货号：
Z36669
中文名称：
IGF1R (Ab-1161)抗体
英文名称：
Anti-IGF1R (Ab-1161) Antibody (Clone#OTI4C4)
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-IGF1R (Ab-1161) Antibody (Clone#OTI4C4) |
| 指标别名 | CD221;IGF I receptor;IGF1R;IGFIR;IGFR;JTK13 |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | IGF1R |
| 克隆号 | OTI4C4 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG1 |
| 免疫原 | Human recombinant protein fragment corresponding to amino acids 741-935 of human IGF1R(NP_000866) produced in Insect. |
| 实际分子量 | 81KD |
| 成分 | PBS (PH 7.3) containing 1% BSA,50% glycerol and 0.02% sodium azide. |
| 纯化方式 | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | Stable for 12 months from date of receipt.Store at -20℃ as received. |
| 背景资料 | IGF1R(Insulin-like Growth Factor 1(IGF-1) Receptor) is a protein found on the surface of human cells.It is a transmembrane receptor that is activated by a hormone called Insulin-like growth factor 1(IGF-1) and by a related hormone called IGF-2.It belongs to the large class of tyrosine kinase receptors.The IGF1R gene is mapped on 15q26.3.IGF-1 plays an important role in growth and continues to have anabolic effects in adults - meaning that it can induce hypertrophy of skeletal muscle and other target tissues.Using a yeast 2-hybrid system,Dey et al.(1998) identified a regulatory subunit of phosphatidylinositol(PI) 3-kinase,PIK3R3,as a binding partner of IGF1R.Functional interaction between BRCA1 and SP1 in the regulation of the IGF1R gene was studied in Schneider cells,a Drosophila cell line which lacks endogenous SP1.In these cells,BRCA1 suppressed 45% of the SP1-induced trans-activation of the IGF1R promoter.Overexpression of the Grb10-binding fragment of Gigyf1 resulted in a significant increase in Igf1-stimulated Igf1r tyrosine phosphorylation.Like the insulin receptor,the IGF-1 receptor is a receptor tyrosine kinase - meaning it signals by causing the addition of a phosphate molecule on particular tyrosines.IGF-1 activates the Insulin receptor at approximately 0.1x the potency of insulin.Part of this signaling may be via IGF1R-InsulinReceptor heterodimers. |
| Uniprot ID | P08069 |
| 基因名全称 | insulin-like growth factor 1 receptor |
| 蛋白名全称 | Insulin-like growth factor 1 receptor |
| 推荐稀释比 | Western blot (WB) 1:2000 |
相关搜索：IGF1R (Ab-1161)抗体，IGF1R (Ab-1161)单抗，Anti-IGF1R (Ab-1161) Antibody (Clone#OTI4C4)