产品货号：
Z36455
中文名称：
PRDX3抗体
英文名称：
Anti-PRDX3 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PRDX3 Antibody |
| 指标别名 | Antioxidant protein 1;AOP 1;AOP1;HBC189;MER5;Peroxiredoxin 3;Peroxiredoxin III;PRDX3;PRO1748;Protein MER5 homolog;Prx III;PRX3;SP 22 |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC,ICC/IF,IP,FCM |
| 基因名称 | PRDX3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human Peroxiredoxin 3 Involved in redox regulation of the cell.Protects radical-sensitive enzymes from oxidative damage by a radical-generating system.Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. |
| 实际分子量 | 26KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | PRDX3(peroxiredoxin 3) also known as AOP-1,MER5,SP-22 or PRX3,is localized exclusively in mitochondria.The deduced 256-amino acid human AOP1 protein shares 86% amino acid sequence similarity with mouse Aop1,and significant similarity with both the human proliferation-associated gene A product and the mouse stress-induced peritoneal macrophage protein Msp23.The PRDX3 gene is mapped on 10q26.11.Expression of PRDX3 is induced by MYC and is reduced in c-myc -/- cells.Chromatin immunoprecipitation analysis spanning the entire PRDX3 genomic sequence revealed that MYC binds preferentially to a 930-bp region surrounding exon 1.Results using mitochondria-specific fluorescent probes demonstrated that PRDX3 is essential for maintaining mitochondrial mass and membrane potential in transformed rat and human cells.These data provided evidence that PRDX3 is a MYC target gene that is required to maintain normal mitochondrial function. |
| Uniprot ID | P30048 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:20～100 Immunocytochemistry/Immunofluorescence(ICC/IF) 1:20～100 Immunocoprecipitation 1:20 Flow cytometry (FCM) 1:20 |
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