产品货号：
Z36421
中文名称：
ISG15抗体(N-term)
英文名称：
Anti-ISG15 Antibody(N-term)(Clone#1031CT2.8.3)
产品规格：
50μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-ISG15 Antibody (N-term)) (Clone#1031CT2.8.3) |
| 指标别名 | G1P2;hUCRP;IFI15;IP17;ISG15;ISG15 ubiquitin like modifier;Ubiquitin like protein ISG15;UCRP |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB,IF |
| 基因名称 | ISG15 |
| 克隆号 | 1031CT2.8.3 |
| 抗体来源 | Mouse |
| 免疫原 | This ISG15 antibody is generated from a mouse immunized with a recombinant protein from human ISG15. |
| 计算分子量 | 18kDa |
| 成分 | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein G column,followed by dialysis against PBS |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein.ISGylation involves a cascade of enzymatic reactions involving E1,E2,and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein.Its target proteins include IFIT1,MX1/MxA,PPM1B,UBE2L6,UBA7,CHMP5,CHMP2A,CHMP4B and CHMP6.Can also isgylate:EIF2AK2/PKR which results in its activation,DDX58/RIG-I which inhibits its function in antiviral signaling response,EIF4E2 which enhances its cap structure-binding activity and translation- inhibition activity,UBE2N and UBE2E1 which negatively regulates their activity,IRF3 which inhibits its ubiquitination and degradation and FLNB which prevents its ability to interact with the upstream activators of the JNK cascade therby inhibiting IFNA- induced JNK signaling.Exhibits antiviral activity towards both DNA and RNA viruses,including influenza A,HIV-1 and Ebola virus.Restricts HIV-1 and ebola virus via disruption of viral budding.Inhibits the ubiquitination of HIV-1 Gag and host TSG101 and disrupts their interaction,thereby preventing assembly and release of virions from infected cells.Inhibits Ebola virus budding mediated by the VP40 protein by disrupting ubiquitin ligase activity of NEDD4 and its ability to ubiquitinate VP40.ISGylates influenza A virus NS1 protein which causes a loss of function of the protein and the inhibition of virus replication.The secreted form of ISG15 can:induce natural killer cell proliferation,act as a chemotactic factor for neutrophils and act as a IFN-gamma-inducing cytokine playing an essential role in antimycobacterial immunity. |
| Uniprot ID | P05161 |
相关搜索：ISG15抗体(N-term)，ISG15单抗，Anti-ISG15 Antibody(N-term)(Clone#1031CT2.8.3)