产品货号：
Z36301
中文名称：
RLTPR/CARMIL2 Purified抗体
英文名称：
Anti-RLTPR/CARMIL2 Purified Antibody (Clone#EM-53)
产品规格：
0.1mg(C100)
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-RLTPR/CARMIL2 Purified Antibody (Clone#EM-53) |
| 指标别名 | CARMIL2,LRRC16C |
| 克隆性 | Monoclonal |
| 检验物种 | mouse,human |
| 应用范围 | FCM,WB |
| 基因名称 | CARMIL2 |
| 克隆号 | EM-53 |
| 抗体来源 | Mouse |
| 免疫原 | Murine RLTPR.The mouse monoclonal antibody EM-53 recognizes RLTPR/CARMIL2,an intracellular protein playing a role in actin filament elongation. |
| 计算分子量 | 155kDa |
| 成分 | Phosphate buffered saline (PBS),pH7.4,15mM sodium azide |
| 纯化方式 | Purified by protein-A affinity chromatography. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | Store at 2～8℃.Do not freeze. |
| 背景资料 | RLTPR/CARMIL2 (RGD motif,leucine rich repeats,tropomodulin domain and proline-rich containing;capping protein regulator and myosin 1 linker 2),also known as LRRC16C,is a cytosolic protein,which with high affinity binds CAPZA2 (capping protein muscle actin Z-line alpha 2) and decreases CAPZA2 affinity for actin barbed ends.RLTPR/CARMIL2 increases the rate of actin filament elongation from seeds in the presence of CAPZA2,however,seems unable to nucleate filaments.Its interaction with CAPZA2 is essential for lamellipodial protrusion and cell translocation.RLTPR/CARMIL2 is crutial for T cell costimulation via CD28 and this property seems to be independent on its actin-uncapping function.The lack of functional RLTPR/CARMIL2 molecules impeded the differentiation toward Th1 and Th17 fates of both human and murine CD4+ T cells and leads to combined immunodeficiency.Expression of RLTPR/CARMIL2 was also detected in human and murine B cells,but it seems not to be involved in BCR-mediated signaling. |
| Uniprot ID | Q6F5E8 |
| 基因名全称 | Capping protein regulator and myosin 1 linker 2 |
| 蛋白名全称 | Capping protein,Arp2/3 and myosin-I linker protein 2 |
| 推荐稀释比 | Flow cytometry:1～4μg/mL.Intracellular staining. |
相关搜索：RLTPR/CARMIL2 Purified抗体，RLTPR抗体，CARMIL2 Purified单抗