产品货号：
Z36288
中文名称：
PRKG1抗体
英文名称：
Anti-PRKG1 Antibody (Clone#OTI9G4)
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PRKG1 Antibody (Clone#OTI9G4) |
| 指标别名 | cGK 1;cGK1;CGKI;cGKI alpha;cGKI BETA;PGK;PKG;PRKG1;PRKG1B;PRKGR1A;PRKGR1B;Protein Kinase G1 alpha |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,IF |
| 基因名称 | PRKG1 |
| 克隆号 | OTI9G4 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG1 |
| 免疫原 | Full length human recombinant protein of human PRKG1 (NP_006249) produced in HEK293T cell. |
| 实际分子量 | 77.6KD |
| 成分 | PBS (pH7.3) containing 1% BSA,50% glycerol and 0.02% sodium azide. |
| 纯化方式 | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | Stable for 12 months from date of receipt.Store at -20℃ as received. |
| 背景资料 | cGMP-dependent protein kinase 1,alpha isozyme is an enzyme that in humans is encoded by the PRKG1 gene.Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha,Ibeta,and II).These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types.This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing.A separate gene on human chromosome 4,PRKG2,encodes the membrane-bound PRKG isoform II.The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone,preventing platelet aggregation,and modulating cell growth.This gene is most strongly expressed in all types of smooth muscle,platelets,cerebellar Purkinje cells,hippocampal neurons,and the lateral amygdala.Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. |
| Uniprot ID | Q13976 |
| 基因名全称 | protein kinase cGMP-dependent 1 |
| 蛋白名全称 | cGMP-dependent protein kinase 1 |
| 推荐稀释比 | Western blot (WB) 1:3000 Immunohistochemistry in paraffin section (IHC) 1:50 Immunofluorescence (IF) 1:100 |
相关搜索：PRKG1抗体，PRKG1单抗，Anti-PRKG1 Antibody (Clone#OTI9G4)