产品货号：
Z36217
中文名称：
PIN1抗体
英文名称：
Anti-PIN1 Antibody (Clone#5E5)
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PIN1 Antibody (Clone#5E5) |
| 指标别名 | DOD;PIN1;PPIase Pin1;Rotamase Pin1;UBL5 |
| 克隆性 | Monoclonal |
| 检验物种 | human,monkey,rat |
| 应用范围 | WB,ICC/IF,FCM |
| 基因名称 | PIN1 |
| 克隆号 | 5E5 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG2b |
| 免疫原 | E.coli-derived human Pin1 recombinant protein (Position:M1-E163).Human Pin1 shares 95% amino acid (aa) sequence identity with mouse Pin1. |
| 实际分子量 | 18KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1,also called DOD,is an enzyme that in humans is encoded by the PIN1 gene.It is mapped to 19p13.2.The enzyme binds to a subset of proteins and thus plays a role as a post phospho PIN1rol in regulating protein function.Studies have shown that the deregulation of PIN1 may play a pivotal role in various diseases.Notably,the up-regulation of PIN1 may be implicated in certain cancers,and the down-regulation of Pin1 may be implicated in Alzheimer's disease.Inhibitors of PIN1 may have therapeutic implications for cancer and immune disorders.PIN1 activity regulates the outcome of proline-directed kinase (e.g.MAPK,CDK or GSK3) signalling and consequently regulates cell proliferation (in part through control of cyclin D1 levels and stability) and cell survival.PIN1 also has an essential role in maintaining cell proliferation and regulating cyclin D1 function. |
| Uniprot ID | Q13526 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (ZN1928) for Western blot,and HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (ZN1866) for ICC. |
| 基因名全称 | peptidylprolyl cis/trans isomerase,NIMA-interacting 1 |
| 蛋白名全称 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells |
相关搜索：PIN1抗体，PIN1单抗，Anti-PIN1 Antibody (Clone#5E5)