产品货号：
Z36194
中文名称：
PD-L1/CD274抗体
英文名称：
Anti-PD-L1/CD274 Antibody (Clone#4F2)
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PD-L1/CD274 Antibody (Clone#4F2) |
| 指标别名 | B7 H;B7 H1;B7 homolog 1;B7H1;CD274;CD274 molecule;PD L1;PDCD1 ligand 1;PDCD1L1;PDCD1LG1;PDL1;PD-L1;PD-L1/CD274;Programmed death ligand 1 |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | ELISA,WB,IHC,ICC,IF,FCM |
| 基因名称 | CD274 |
| 克隆号 | 4F2 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG1 |
| 免疫原 | PD-L1 antibody was raised against the extracellular domain of human PD-L1. |
| 计算分子量 | 33kDa |
| 成分 | PD-L1 Antibody is supplied in PBS containing 0.02% sodium azide and 50% glycerol. |
| 纯化方式 | PD-L1 Antibody is supplied as protein A purified IgG1. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC) (1).T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC (2).PD-1 can bind two different but related ligands,PD-L1 and PD-L2.PD-L1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells (3).This suggests that PD-L1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells,thereby reducing the likelihood of host immune responses to allografts.PD-L1 also functions as an immune checkpoint protein,and multiple anti-PD-L1 antibodies are currently in phase II and III clinical trials,with one antibody already approved for the treatment of cancer (4). |
| Uniprot ID | Q9NZQ7 |
| 基因名全称 | Programmed cell death 1 ligand |
| 蛋白名全称 | Programmed cell death 1 ligand |
| 推荐稀释比 | PD-L1 antibody can be used for detection of PD-L1 by Western blot at 0.25 ～ 0.5μg/mL.Antibody can also be used for immunohistochemistry starting at 2 ～ 5μg/mL.For immunofluorescence start at 5μg/mL.Antibody validated:Western Blot in human samples;Immunohistochemistry in human samples;Immunocytochemistry in human samples;Immunofluorescence in human samples and Flow Cytometry in mouse samples.All other applications and species not yet tested. |
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