产品货号：
Z36181
中文名称：
PSMA/GCPII/FOLH1 Purified抗体
英文名称：
Anti-PSMA/GCPII/FOLH1 Purified Antibody (Clone#GCP-04)
产品规格：
0.1mg(C100)
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PSMA/GCPII/FOLH1 Purified Antibody (Clone#GCP-04) |
| 指标别名 | FGCP;Folate hydrolase 1;FOLH;FOLH1;GCP2;GCPII;Glutamate carboxypeptidase 2;Glutamate carboxypeptidase II;mGCP;NAALAD1;NAALAdase;NAALADase I;PSM;PSMA |
| 克隆性 | Monoclonal |
| 检验物种 | pig,mouse,rat,human |
| 应用范围 | WB,IHC,ICC |
| 基因名称 | FOLH1 |
| 克隆号 | GCP-04 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG1 |
| 免疫原 | Recombinant fragment of human GCPII (amino acids 44-750) produced in S2 cells.The mouse monoclonal antibody GCP-04 recognizes amino acids 100-104 of extracellular domain of denaturated glutamate carboxypeptidase II (PSMA,NAALADase,FOLH1),an approximately 95～110kDa transmembrane glycoprotein. |
| 计算分子量 | 84kDa |
| 成分 | Phosphate buffered saline (PBS),pH7.4,15mM sodium azide |
| 纯化方式 | Purified by protein-A affinity chromatography. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | Store at 2～8℃.Do not freeze. |
| 背景资料 | Glutamate carboxypeptidase II (GCPII),also known as N-acetyl-alpha-linked acidic dipeptidase I (NAALADase I),folate hydrolase (FOLH1),and prostate-specific membrane antigen (PSMA),is an approximately 95～110kDa type II transmembrane glycoprotein expressed in various tissues.In nervous system GCPII cleaves abundant N-acetylaspartylglutamate,which is released from neurons in a calcium-dependent manner,to N-acetylaspartate and glutamate.As immoderate glutamate concentration is neurotoxic,GCPII contributes to pathological conditions regarding e.g.Alzheimer∩s disease,Huntington∩s disease,epilepsy,schizophrenia,stroke or neuropathic pain and appears to be an interesting therapeutic target.In jejunum GCPII hydrolyzes pteroylpoly-gamma-glutamate to folate and glutamate,enabling folate to be absorbed by gastrointestinal tract.GCPII,which is present in a number of tissues at low levels,is overexpressed in neovasculature of most solid tumours and is a target enzyme for diagnosis and treatment of prostate cancer.Normal human prostate express more mRNA coding for a cytosolic GCPII form truncated at the N-terminus (PSM∩) than mRNA for membrane-bound GCPII,and this ratio is reversed upon malignant transformation. |
| Uniprot ID | Q04609 |
| 基因名全称 | Folate hydrolase 1 |
| 蛋白名全称 | Glutamate carboxypeptidase 2 |
| 推荐稀释比 | Western blotting:1μg/mL;positive control:LNCaP cell line.Sample preparation:Resuspend approx.50 mil.cells in 1mL cold lysis buffer (1% NP-40).Incubate 30min on ice.Mix lysate with non-reducing/reducing Laemmli SDS-PAGE sample buffer.Both reducing and non-reducing conditions. |
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